Document Detail

Measurement of the great vessels in the mediastinum could help distinguish true from false-positive coarctation of the aorta in the third trimester.
MedLine Citation:
PMID:  19778876     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated the utility of analyzing prenatal mediastinal measures of the great arteries in distinguishing true coarctation of the aorta (CoA) from false-positive CoA. METHODS: All fetuses in this study had suspicion of CoA based on the presence of right-left heart disproportion. We defined 3 study groups: group 1, true fetal CoA; group 2, false-positive fetal CoA with a narrow aortic arch; and group 3, false-positive fetal CoA without a narrow aortic arch. RESULTS: In group 1, the mean mediastinal pulmonary artery (PA) to ascending aorta (Ao) diameter ratio +/- SD was 2.03 +/- 0.48, and in group 2, the ratio was 1.60 +/- 0.23. The difference was statistically significant (P = .0018, t test). In group 3, the mean PA:Ao ratio was 1.35 +/- 0.14. The difference between groups 1 and 3 was statistically significant (P = .0002, t test). In our study group, for a PA:Ao ratio of 1.60, sensitivity was 83.0%; specificity, 85.0%; positive predictive value, 62.5%; and negative predictive value, 94.0%. CONCLUSIONS: In the third trimester, the main PA:Ao ratio as measured in the fetal mediastinum can be a helpful tool in distinguishing true CoA requiring neonatal cardiac surgery from false-positive CoA and simple disproportion requiring medical attention but no surgery in the first month of postnatal life.
Maciej Slodki; Jack Rychik; Tomasz Moszura; Katarzyna Janiak; Maria Respondek-Liberska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  28     ISSN:  1550-9613     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2009-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1313-7     Citation Subset:  IM    
Department of Diagnosis and Prevention of Congenital Malformations, Medical University of Lodz, Polish Mother's Memorial Hospital, Lodz, Poland.
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MeSH Terms
Aortic Coarctation / ultrasonography*
False Negative Reactions
False Positive Reactions
Mediastinum / abnormalities*,  blood supply,  ultrasonography*
Pregnancy Trimester, Third*
Reproducibility of Results
Sensitivity and Specificity
Statistics as Topic
Transposition of Great Vessels / ultrasonography*
Ultrasonography, Prenatal / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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