Document Detail

Measurement of glycine in human prefrontal brain by point-resolved spectroscopy at 7.0 tesla in vivo.
MedLine Citation:
PMID:  19780175     Owner:  NLM     Status:  MEDLINE    
Measurement of glycine in human frontal brain by an optimized point-resolved spectroscopy sequence at 7 T is reported. Echo time dependencies of the overlapping coupled resonances of myo-inositol, free choline, and threonine were investigated with density matrix simulations, incorporating the slice-selective radiofrequency and gradient pulses. The numerical simulations indicated that the selectivity of the 3.55-ppm glycine singlet is maximized at (TE(1), TE(2)) = (101, 51) ms. Phantom experiments indicated that the myo-inositol peak amplitude between 3.5 and 3.6 ppm is reduced by a factor of 30 following the optimized point-resolved spectroscopy, as predicted by the simulation. From LCModel analyses, the glycine concentration in the medial prefrontal cortex in healthy adults was estimated, with a mean Cram??r-Rao lower bound of 7 +/- 1% (mean +/- standard deviation; n = 7), to be 0.8 +/- 0.1 mM, with reference to total creatine at 8 mM.
Changho Choi; Deborah Douglas; Halima Hawesa; Ashish Jindal; Charles Storey; Ivan Dimitrov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  62     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-03     Completed Date:  2010-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1305-10     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
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MeSH Terms
Glycine / analysis*
Magnetic Resonance Spectroscopy / methods*
Prefrontal Cortex / metabolism*
Tissue Distribution
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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