| Measurement of glomerular filtration rate using dynamic magnetic resonance imaging in patients with chronic kidney disease. | |
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MedLine Citation:
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PMID: 21058262 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Determination of glomerular filtration rate (GFR) using plasma disappearance curves requires the injection of a filtration marker and repeated timed blood collections. Gadolinium-containing contrast media are excreted exclusively by glomerular filtration and could provide a novel approach to quantifying GFR using magnetic resonance (MR) imaging. The aim of this study was to demonstrate the feasibility of measuring GFR by the clearance of gadolinium-containing contrast medium in patients with chronic kidney disease (CKD).?Methods: Informed consent was obtained from stable CKD patients in stages 1, 2 or 3 (n=16; 5 women, 11 men; median age 54 years). GFR was measured after a bolus injection of gadobutrol (4 mL, approximately 0.05 mmol/kg) and calculated from the washout of the signal intensity obtained over the liver. The obtained MR-GFR was compared with simultaneously measured plasma clearance of inulin and gadobutrol.?Results: Technical failure occurred in 2 patients. The mean obtained MR-GFR was 71 ± 25 (SD) mL/min per 1.73 m² and agreed well with the mean inulin-GFR (70 ± 24 mL/min per 1.73 m²). Pearson's correlation coefficient was r=0.91. The mean of the paired differences was 1 ± 10 mL/min per 1.73 m² and not significantly different from zero. GFR obtained from gadobutrol plasma clearance also agreed well with inulin-GFR and MR-GFR (r=0.92 and r=0.75, respectively).?Conclusions: We describe a novel method of determining GFR from MR imaging using a low dose of gadobutrol in patients with reduced GFR that enables the absolute quantification of GFR after routine contrast-enhanced MR imaging. |
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Authors:
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Ferruh Artunc; Serdar Yildiz; Andreas Boss; Thomas Frenzel; Heinz-Peter Schlemmer; Fritz Schick; Teut Risler; Hans-Ulrich Häring; Cristina Rossi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nephrology Volume: 24 ISSN: 1724-6059 ISO Abbreviation: J. Nephrol. Publication Date: 2011 Jul-Aug |
Date Detail:
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Created Date: 2011-07-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9012268 Medline TA: J Nephrol Country: Italy |
Other Details:
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Languages: eng Pagination: 482-9 Citation Subset: IM |
Affiliation:
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1 Department of Internal Medicine IV, Section of Nephrology and Hypertension, University of Tuebingen, Tuebingen - Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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