| Measurement of gastric-to-end-tidal carbon dioxide difference in neonates requiring intensive care. | |
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MedLine Citation:
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PMID: 22348539 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective: Gastric-arterial partial CO(2) pressure gap (P(g-a)CO(2) gap) measured by gastric tonometry may detect the disturbance of splanchnic perfusion. Since in the neonatal age it is very difficult to follow up the circulatory condition with frequent acid-base examinations, we wanted to compare the P(g-a)CO(2) gap with an alternative gap of P(g)CO(2)- end-tidal carbon dioxide (P(g)(-ET)CO(2)gap). Methods: A prospective study was performed on ventilated neonates requiring intensive therapy (n=44, weight: 1813±977 g). P(ET)CO(2) and P(g)CO(2) were measured with a side stream capnograph. We applied a newly developed gastric tonometric probe. Patients were divided into group 1 of patients in stable condition (n=35) and group 2 of patients with severe condition (i.e. CRIB score higher than 10; n=9). For main statistical analysis a mixed model repeated measurements ANOVA, Bland-Altman analysis were applied. Results: P(g)(-ET)CO(2)gap was higher than P(g-a)CO(2) gap (11.40±7.79 versus 3.63±7.98 mmHg, p<0.01). Both gaps were higher in group 2 (8.71±10.89 and 18.27±10.49 versus 2.53±6.78 and 9.92±6.22 mmHg, p<0.01 and p<0.05). Bland-Altman analysis of the two gaps showed an acceptable correspondence. Conclusions: P(g)(-ET)CO(2) gap may be used as a method for continuous estimation of splanchnic perfusion and a prognostic index also in critically ill neonates. However, the P(g-a)CO(2) gap should not be abandoned. |
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Authors:
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Orsolya Szakál; Agnes Király; Dániel Szűcs; Márta Katona; Domokos Boda; Gyula Tálosi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-21 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Paediatrics, University of Szeged, Hungary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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