| Measurement of gastric emptying of a high-nutrient liquid by 3D ultrasonography in diabetic gastroparesis. | |
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MedLine Citation:
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PMID: 21087356 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background Gastric emptying (GE) is delayed in 30-50% of patients with longstanding diabetes. Scintigraphy represents the 'gold standard' for measurement of GE, but is associated with a radiation burden. Three-dimensional (3D) ultrasonography has recently been demonstrated to provide a valid measure of liquid GE in healthy subjects; however, the technique has not been validated in patients with gastroparesis. The primary aim of this study was to compare measurements of GE of a high-nutrient glucose drink by 3D ultrasonography and scintigraphy in diabetic gastroparesis. Methods Ten patients (eight type 1, two type 2, 6M, 4F, aged 46.1 ± 4.5 years, BMI 29.1 ± 1.6 kg m(-2) , duration 19.6 ± 3.3 years) with diabetic gastroparesis [defined as retention at 100 min of solid (100 g minced beef) ≥61% and/or 50% emptying time (T50) of liquid (150 mL 10% dextrose) ≥31 min], were studied. Concurrent measurements of GE by scintigraphy and 3D ultrasonography were performed following ingestion of 75 g glucose in 300 mL water labeled with 20 MBq (99m) Tc-sulfur colloid. Key Results There was no significant difference in GE between the two techniques (T50s: scintigraphy - 103.3 ± 10.0 min VS 3D ultrasonography - 98.8 ± 10.4 min; P = 0.60). There was a significant correlation between scintigraphic and ultrasonographic T50s (r = 0.67, P = 0.03). The limits of agreement for the T50s were -57.22 min and +48.22 min (mean difference -4.5 min). Blood glucose after the drink was greater when GE was relatively more rapid (e.g. at t = 60 min; scintigraphy: r = -0.65, P = 0.04; 3D ultrasonography: r = -0.78, P = 0.008). Conclusions & Inferences Three-dimensional ultrasonography appears to provide a valid, and non-invasive, measure of GE of high-nutrient liquids in diabetic gastroparesis. |
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Authors:
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J E Stevens; O H Gilja; D Gentilcore; T Hausken; M Horowitz; K L Jones |
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Publication Detail:
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Type: Journal Article Date: 2010-11-19 |
Journal Detail:
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Title: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society Volume: 23 ISSN: 1365-2982 ISO Abbreviation: Neurogastroenterol. Motil. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9432572 Medline TA: Neurogastroenterol Motil Country: England |
Other Details:
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Languages: eng Pagination: 220-e114 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Discipline of Medicine, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia Institute of Medicine, University of Bergen, Bergen, Norway National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway Nutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, University of South Australia, Adelaide, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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