| Measurement of functional residual capacity by nitrogen washout during partial ventilatory support. | |
| | |
MedLine Citation:
|
PMID: 12595980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Evaluation of an open circuit multiple breath nitrogen washout (MBNW) technique for measurement of functional residual capacity (FRC) during partial ventilatory support using corrections for gas viscosity, sampling delay time, and re-inspired nitrogen. DESIGN: Measurements in a lung model with known reference volume simulating spontaneous breathing and duplicate measurements in patients breathing spontaneously with partial ventilatory support. SETTING. Experimental laboratory and intensive care units of a university hospital. PATIENTS: Eighteen patients with acute respiratory failure. INTERVENTIONS: Change of FiO(2) from baseline to 1.0. MEASUREMENTS AND MAIN RESULTS: FRC was measured by MBNW during spontaneous breathing with continuous positive airway pressure, pressure support ventilation, proportional assist ventilation, automatic tube compensation, and airway pressure release ventilation. In the lung model, repeated measurements at three volumes were done with all partial ventilatory support modalities, and baseline FiO(2 )was varied with one mode and FRC. The mean of differences between MBNW (FRC(MBNW)) and reference was 28 ml (1.6%), and the 2.SD-interval was 84 ml (4.9%) for all modes. Measurements up to a baseline FiO(2) of 0.8 showed differences of 5 ml (-0.3%) and the 2.SD-interval of 38 ml (2.2%) between reference and FRC(MBNW). In 18 patients, 66 duplicate measurements revealed a mean difference of 30 ml (0.9%) with a coefficient of repeatability of 358 ml (13%) independent of ventilatory mode and chronological order. CONCLUSION: This study suggests that, using corrections for gas viscosity, sampling delay time, and re-inspired nitrogen, FRC can be determined with good repeatability in patients and good accuracy in a lung model during partial ventilatory support. |
| | |
Authors:
|
Jörg Zinserling; Hermann Wrigge; Dirk Varelmann; Rudolf Hering; Christian Putensen |
Publication Detail:
|
Type: Journal Article Date: 2003-02-21 |
Journal Detail:
|
Title: Intensive care medicine Volume: 29 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 2003 May |
Date Detail:
|
Created Date: 2003-05-15 Completed Date: 2003-09-23 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 720-6 Citation Subset: IM |
Affiliation:
|
Klinik und Poliklinik für Anästhesiologie und Spezielle Intensivmedizin, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. jzinserling@uni-bonn.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Critical Care Functional Residual Capacity* Humans Intensive Care Units Middle Aged Models, Biological* Nitrogen / metabolism* Pulmonary Gas Exchange* Reproducibility of Results Respiration, Artificial / instrumentation* Respiratory Distress Syndrome, Adult / therapy* |
| Chemical | |
Reg. No./Substance:
|
7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Infectious diseases as a trigger in thrombotic microangiopathies in intensive care unit (ICU) patien...
Next Document: Ventilator-associated pneumonia and atelectasis: evaluation through bronchoalveolar lavage fluid ana...