Document Detail


Measurement of forelimb function by digital video motion analysis in rat nerve transection models.
MedLine Citation:
PMID:  18346235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The object of this study was to demonstrate that digital video motion analysis is a quantitative, valid, and reproducible method for evaluation of function in the rat model of forelimb nerve transection and repair. Median, ulnar, and radial nerves were transected and directly repaired in 220 g Sprague-Dawley rats. Normal rats and sham-operated rats served as controls (six rats in each group). Two-dimensional (2D) digital video motion analysis was used to capture the gait cycle and quantify joint movement and changes in toe spread. Recordings were made preoperatively and at 1, 4, 8, 12, and 16 weeks postoperatively. Wrist and metacarpophalangeal (MP) joint extension decreased after radial nerve injury, and wrist and MP joint flexion decreased after combined median and ulnar nerve injury or injury to the median nerve only. Toe spread decreased after combined median and ulnar nerve injury and after radial nerve injury. Median or ulnar nerve injury alone did not lead to a significant change in toe spread. 2D digital video motion analysis can be used to quantify movement of the wrist and the MP joint in rats. It is a valid method to evaluate functional deficit and recovery after nerve injury and repair in the forelimb.
Authors:
Huan Wang; Robert J Spinner; Eric J Sorenson; Anthony J Windebank
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the peripheral nervous system : JPNS     Volume:  13     ISSN:  1529-8027     ISO Abbreviation:  J. Peripher. Nerv. Syst.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9704532     Medline TA:  J Peripher Nerv Syst     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-102     Citation Subset:  IM    
Affiliation:
Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Forelimb / innervation,  physiology*
Median Nerve / injuries,  physiology
Motion
Movement / physiology*
Peripheral Nerves / injuries*,  physiology
Radial Nerve / injuries,  physiology
Rats
Rats, Sprague-Dawley
Research Design*
Ulnar Nerve / injuries,  physiology
Video Recording / instrumentation,  methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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