Document Detail


Measurement ex-vivo of the inhibition of fatty acid biosynthesis by bezafibrate administration in different rat tissues.
MedLine Citation:
PMID:  2886626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The action of bezafibrate on fatty acid biosynthesis pathways has been examined in rat tissues. The drug abolished the induction of fatty acid synthesis that occurs on refeeding the animals with a high carbohydrate diet and by insulin administration in liver and adipose tissue. The rates of fatty acid biosynthesis in these tissues were estimated from the incorporation of 3H into lipids from 3H2O.
Authors:
A Ayala; A Machado
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  39     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-09-14     Completed Date:  1987-09-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  551-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Animals
Bezafibrate / pharmacology*
Fatty Acids / biosynthesis*
Female
Insulin / pharmacology
Liver / metabolism
Oxidation-Reduction
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Fatty Acids; 11061-68-0/Insulin; 41859-67-0/Bezafibrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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