Document Detail


Measurement of entropy production in living cells under an alternating electric field.
MedLine Citation:
PMID:  23364867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Entropy is a thermodynamic property toward equilibrium based on the dissipation of energy. Cells constitute such a thermodynamic system, in which entropy production is both inevitable and highly significant. Although the experimental measurement of entropy production in a cell is very difficult, a new method to accomplish this in living cells is reported herein. Through heating the sample by alternating electric fields and recording the heat flow from cells, the entropy production in two normal cell lines, MCF10A and HL-7702, and two cancerous cell lines, MDA-MB-231 and SMMC-7721, was measured and compared. The scaled electroinduced entropy production rate (SEEP) of cancer cells monotonically increases with electric field strength at 5-40 V/cm, while that of normal cells changes nonmonotonically with electric field strength, reaching a peak at 5-30 V/cm. For all cell lines, the cancerous-to-normal ratio of field-induced entropy production is clearly <1 in a large range of field strength from 5 to 25 V/cm. Therefore, this work presents an easy and effective strategy for experimentally investigating the thermodynamic properties of the cell, and gives deeper insight into the physical differences between normal and cancerous cells exposed to electric fields.
Authors:
Changjiang Ding; Liaofu Luo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-30
Journal Detail:
Title:  Cell biology international     Volume:  37     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-12     Completed Date:  2014-01-28     Revised Date:  2014-07-10    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Copyright Information:
© 2013 International Federation for Cell Biology.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Cell Line, Tumor
Cell Physiological Phenomena*
Electric Stimulation
Humans
Models, Biological
Thermodynamics
Comments/Corrections
Comment In:
Cell Biol Int. 2014 Jul;38(7):898-9   [PMID:  24687429 ]

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