Document Detail

Measurement of dietary and dentifrice effects upon calculus accumulation rates in the domestic ferret.
MedLine Citation:
PMID:  2307747     Owner:  NLM     Status:  MEDLINE    
Most animal models for the study of calculus accumulation and control currently use rodents or dogs. In an effort to overcome limitations inherent in the use of these species, we investigated calculus formation in domestic ferrets, a species used by King et al. in the 1940's and 1950's. Ferrets are much smaller than dogs, and, unlike rodents, can be scored while alive. In this study, we examined the kinetics of calculus formation in female ferrets fed with moist canned cat food--either plain or supplemented with sucrose--and two combinations of mineral salts. An additional group given supplemented cat food was treated twice daily with regular Crest toothpaste. Animals were sedated with a 1:1 mixture of ketamine and xylazine solutions and given a mechanical prophylaxis prior to the trial period, then scored for area and extent of calculus accumulation at two, four, six, and eight weeks thereafter. The data showed that the mineral-supplemented groups accumulated calculus at a significantly faster rate than the unsupplemented or dentifrice-treated groups, but the differences were no longer significant at eight weeks. This demonstrated that the ferret is a suitable model for the study of calculus, that dietary mineral content influenced calculogenesis, and that the application of regular dentifrice initially slowed, but did not prevent, calculus accumulation.
D S Harper; P H Mann; S Regnier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dental research     Volume:  69     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-02     Completed Date:  1990-04-02     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-50     Citation Subset:  D; IM    
Fairleigh Dickinson University, Oral Health Research Center, Hackensack, New Jersey 07601.
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MeSH Terms
Analysis of Variance
Calcium Phosphates / pharmacology
Dental Calculus / physiopathology*
Dentifrices / pharmacology*
Diet, Cariogenic*
Disease Models, Animal*
Magnesium Sulfate / pharmacology
Minerals / pharmacology
Sucrose / pharmacology
Toothpastes / pharmacology*
Reg. No./Substance:
0/Calcium Phosphates; 0/Dentifrices; 0/Minerals; 0/Toothpastes; 0/alpha-tricalcium phosphate; 0/monocalcium phosphate; 0/tetracalcium phosphate; 57-50-1/Sucrose; 7487-88-9/Magnesium Sulfate; 97Z1WI3NDX/calcium phosphate; L11K75P92J/dicalcium phosphate anhydrous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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