Document Detail

Measurement of coronary flow response to cold pressor stress in asymptomatic women with cardiovascular risk factors using spiral velocity-encoded cine MRI at 3 Tesla.
MedLine Citation:
PMID:  20302399     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Coronary sinus (CS) flow in response to a provocative stress has been used as a surrogate measure of coronary flow reserve, and velocity-encoded cine (VEC) magnetic resonance imaging (MRI) is an established technique for measuring CS flow. In this study, the cold pressor test (CPT) was used to measure CS flow response because it elicits an endothelium-dependent coronary vasodilation that may afford greater sensitivity for detecting early changes in coronary endothelial function.
PURPOSE: To investigate the feasibility and reproducibility of CS flow reactivity (CSFR) to CPT using spiral VEC MRI at 3 Tesla in a sample of asymptomatic women with cardiovascular risk factors.
MATERIAL AND METHODS: Fourteen asymptomatic women (age 38 years +/- 10) with cardiovascular risk factors were studied using 3D spiral VEC MRI of the CS at 3 T. The CPT was utilized as a provocative stress to measure changes in CS flow. CSFR to CPT was calculated from the ratio of CS flow during peak stress to baseline CS flow.
RESULTS: CPT induced a significant hemodynamic response as measured by a 45% increase in rate-pressure product (P<0.01). A significant increase in CS volume flow was also observed (baseline, 116 +/- 26 ml/min; peak stress, 152 +/- 34 ml/min, P=0.01). CSFR to CPT was 1.31 +/- 0.20. Test-retest variability of CS volume flow was 5% at baseline and 6% during peak stress.
CONCLUSION: Spiral CS VEC MRI at 3 T is a feasible and reproducible technique for measuring CS flow in asymptomatic women at risk for cardiovascular disease. Significant changes in CSFR to CPT are detectable, without demanding pharmacologic stress.
Christopher D Maroules; Alice Y Chang; Andrew Kontak; Ivan Dimitrov; Melanie Kotys; Ronald M Peshock
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  51     ISSN:  1600-0455     ISO Abbreviation:  Acta Radiol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-05-06     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  420-6     Citation Subset:  IM    
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MeSH Terms
Blood Flow Velocity / physiology*
Cardiovascular Diseases / physiopathology*
Cold Temperature*
Coronary Circulation / physiology*
Feasibility Studies
Magnetic Resonance Imaging / methods*
Regional Blood Flow / physiology*
Reproducibility of Results
Risk Factors
Vasodilation / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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