| Measurement of coronary flow reserve in the anterior and posterior descending coronary arteries by transthoracic Doppler ultrasound. | |
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MedLine Citation:
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PMID: 12398967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe for the first time transthoracic Doppler ultrasound assessment of coronary flow reserve (CFR) in both the posterior descending (PDA) and left anterior descending (LAD) coronary arteries. CFR (hyperemic/resting diastolic flow velocity ratio) was measured by 90-second intravenous adenosine infusion (140 microg/kg/min). Baseline PDA flow was detected in 62 of 81 subjects (76%), and the CFR was measurable in 44 of them (54%) because of adenosine-induced hyperventilation. According to angiography, these 44 subjects were divided into 3 groups: group 1 (0% to 29% stenosis), group 2 (30% to 69% stenosis), and group 3 (> or =70% stenosis). PDA CFR was 2.62 +/- 0.25 in 17 patients in group 1, 2.33 +/- 0.32 in 9 patients in group 2, and 1.40 +/- 0.54 in 18 patients in group 3 (F = 41.83, p <0.0001). LAD CFR was 3.31 +/- 0.54 in 15 patients in group 1, 2.49 +/- 0.71 in 10 patients in group 2, and 1.12 +/- 0.49 in 19 patients in group 3 (F = 65.68, p <0.0001). A cut-off of <2 identified > or =70% stenosis in both of the arteries supplying the PDA and in the LAD. Noninvasive measurement of PDA CFR is feasible and may improve with technologic advancement and the use of selective adenosine receptor agonists, thus preventing hyperventilation. |
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Authors:
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Paolo Voci; Francesco Pizzuto; Enrica Mariano; Paolo Emilio Puddu; Pier Andrea Chiavari; Francesco Romeo |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 90 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-25 Completed Date: 2002-12-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 988-91 Citation Subset: AIM; IM |
Affiliation:
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Section of Cardiology II, University of Rome "La Sapienza", Rome, Italy. voci@uniroma.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arteries / physiopathology*, ultrasonography* Blood Flow Velocity / physiology* Coronary Angiography Coronary Circulation / physiology* Coronary Stenosis / diagnosis, physiopathology Coronary Vessels / physiopathology*, ultrasonography* Feasibility Studies Female Hemodynamics / physiology Humans Male Middle Aged Predictive Value of Tests Sensitivity and Specificity Ultrasonography, Doppler, Color* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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