Document Detail


Measurement and clinical effect of grey matter pathology in multiple sclerosis.
MedLine Citation:
PMID:  23153407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the past 10 years, the intense involvement of the grey matter of the CNS in the pathology of multiple sclerosis has become evident. On gross inspection, demyelination in the grey matter is rather inconspicuous, and lesions in the grey matter are mostly undetectable with traditional MRI sequences. However, the results of immunohistochemical studies have shown extensive involvement of grey matter, and researchers have developed and applied new MRI acquisition methods as a result. Imaging techniques specifically developed to visualise grey matter lesions indicate early involvement, and image analysis techniques designed to measure the volume of grey matter show progressive loss. Together, these techniques have shown that grey matter pathology is associated with neurological and neuropsychological disability, and the strength of this association exceeds that related to white matter lesions or whole brain atrophy. By focusing on the latest insights into the in-vivo measurement of grey matter lesions and atrophy, we can assess their clinical effects.
Authors:
Jeroen J G Geurts; Massimiliano Calabrese; Elizabeth Fisher; Richard A Rudick
Related Documents :
23296137 - Teaching neuroimages: pseudohypertrophic cerebral cortex in end-stage creutzfeldt-jakob...
24490107 - Imaging of cardiac valves by computed tomography.
14551597 - Utility of magnetic resonance imaging in evaluating inflatable penile prosthesis malfun...
24210437 - Magnetic resonance imaging of female urethral and periurethral disorders.
21921277 - Redefinition of transient ischemic attack improves prognosis of transient ischemic atta...
9170367 - Myelopathy due to hypoplasia of the atlas. a case report.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Lancet. Neurology     Volume:  11     ISSN:  1474-4465     ISO Abbreviation:  Lancet Neurol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-01-18     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1082-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / pathology*
Clinical Trials as Topic / methods
Humans
Multiple Sclerosis / diagnosis,  pathology*,  psychology*
Grant Support
ID/Acronym/Agency:
2P50NS038667-11/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antithrombotic therapy for stroke prevention in non-valvular atrial fibrillation.
Next Document:  Cognitive decline in older adults with a history of traumatic brain injury.