| Measurement of cerebral perfusion with arterial spin labeling: Part 2. Applications. | |
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MedLine Citation:
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PMID: 17445302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arterial spin labeling (ASL) uses magnetic resonance imaging methods to measure cerebral blood flow (CBF) non-invasively. ASL CBF validly localizes brain function and may be especially useful for studies where the time frame of behavioral change is more than a few minutes, such as in longitudinal and treatment studies. ASL measures of cerebral perfusion are highly accurate in detecting lesion laterality in temporal lobe epilepsy, stenotic-occlusive disease, and brain tumors. Among lesioned patients, ASL CBF has excellent concurrent validity when correlated with CBF measured by Positron Emission Tomography or with dynamic susceptibility-weighted magnetic resonance. ASL CBF can predict tumor grading in vivo and can predict six-month response to the surgical treatment of brain tumors. ASL's capability to selectively and non-invasively tag flow in major vessels may refine the monitoring of treatment of cerebrovascular disease and brain tumors. Conclusions about the utility of ASL are limited by the small sample sizes of the studies currently in the literature and by the uncertainty caused by the effect of brain disease on transit times of the magnetic tag. As the method evolves, ASL techniques will likely become more widely used in clinical research and practice. |
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Authors:
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Gregory G Brown; Camellia Clark; Thomas T Liu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the International Neuropsychological Society : JINS Volume: 13 ISSN: 1355-6177 ISO Abbreviation: J Int Neuropsychol Soc Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-20 Completed Date: 2007-06-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9503760 Medline TA: J Int Neuropsychol Soc Country: England |
Other Details:
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Languages: eng Pagination: 526-38 Citation Subset: IM |
Affiliation:
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Psychology Service, VA San Diego Healthcare System, San Diego, California 92161, USA. gbrown@ucsd.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteries Brain / blood supply*, pathology Brain Diseases / diagnosis* Cerebrovascular Circulation / physiology* Cerebrovascular Disorders / diagnosis* Magnetic Resonance Imaging / methods Perfusion* Spin Labels* |
| Grant Support | |
ID/Acronym/Agency:
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1R01 NS051661/NS/NINDS NIH HHS; 1R01 NS367220/NS/NINDS NIH HHS; 1U24 RR021992/RR/NCRR NIH HHS; 5K08 MH01642/MH/NIMH NIH HHS; K08 MH001642-05/MH/NIMH NIH HHS; M01 RR000827-328412/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Spin Labels |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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