| Measurement of cerebral hemodynamics with perfusion-weighted MR imaging: comparison with pre- and post-acetazolamide 133Xe-SPECT in occlusive carotid disease. | |
| | |
MedLine Citation:
|
PMID: 11156764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: We generated regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF) studies from dynamic susceptibility contrast-enhanced MR images after an intravenous bolus injection of contrast agent (perfusion-weighted imaging [PWI]) by applying indicator dilution theory. We used a multishot echo-planar imaging (EPI) sequence to obtain adequate arterial input function (AIF). Our purpose was to compare the cerebral hemodynamics measured by PWI with the rCBF values and cerebral perfusion reserve obtained by xenon-133 single-photon emission CT (133Xe-SPECT). METHODS: Eight patients with chronic internal carotid artery occlusion or stenosis were examined. PWI data were acquired using a multishot EPI sequence, and the AIF was determined automatically. Our procedure was based on indicator dilution theory and deconvolution analysis. To eliminate the effect of superficial vessels, the automatic threshold selection method was used. RESULTS: AIF was adequate to generate rCBF and rCBV images. The rCBF and rCBV images by PWI were superior to 133Xe-SPECT scans in spatial resolution, and the rCBF values obtained by PWI correlated well with those obtained by 133Xe-SPECT. The regions with severely decreased perfusion reserve, which were determined by pre- and post-acetazolamide 133Xe-SPECT, showed significantly lower rCBF and higher rCBV by PWI than did regions with normal and moderately decreased perfusion reserve. CONCLUSION: The rCBF and rCBV images generated by our procedure using PWI data appear to provide important clinical information for evaluating the degree of cerebral perfusion reserve impairment in patients with chronic ischemia. |
| | |
Authors:
|
K Kikuchi; K Murase; H Miki; T Kikuchi; Y Sugawara; T Mochizuki; J Ikezoe; S Ohue |
Related Documents
:
|
20966064 - Cerebral microhemorrhages detected by susceptibility-weighted imaging in amateur boxers. 2056324 - Mri in cerebral toxocaral disease. 17896374 - Comparison of region-of-interest analysis with three different histogram analysis metho... 22575694 - Increasing the signal-to-noise ratio by using vertically stacked phased array coils for... 17362834 - Sensitivity and specificity of dopamine transporter imaging with 123i-fp-cit spect in d... 7641434 - Stress fractures of the femoral diaphysis in young children. a report of 2 cases. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: AJNR. American journal of neuroradiology Volume: 22 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2001 Feb |
Date Detail:
|
Created Date: 2001-02-22 Completed Date: 2001-05-03 Revised Date: 2008-02-14 |
Medline Journal Info:
|
Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
|
Languages: eng Pagination: 248-54 Citation Subset: IM |
Affiliation:
|
Department of Radiology, Ehime University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetazolamide
/
diagnostic use Aged Arterial Occlusive Diseases / diagnosis, physiopathology* Blood Volume Carotid Artery Diseases / diagnosis, physiopathology* Carotid Stenosis / diagnosis, physiopathology Cerebral Arteries / physiopathology Cerebrovascular Circulation* Female Hemodynamics Humans Magnetic Resonance Imaging* Male Middle Aged Tomography, Emission-Computed, Single-Photon Xenon Radioisotopes / diagnostic use |
| Chemical | |
Reg. No./Substance:
|
0/Xenon Radioisotopes; 59-66-5/Acetazolamide |
| Comments/Corrections | |
Comment In:
|
AJNR Am J Neuroradiol. 2001 Feb;22(2):235-6
[PMID:
11156759
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term follow-up of asymptomatic patients with major artery occlusion: rate of symptomatic change...
Next Document: Relationship between vascular enhancement, cerebral hemodynamics, and MR angiography in cases of acu...