Document Detail

Measurement of canine pancreatic perfusion using dynamic computed tomography: Influence of input-output vessels on deconvolution and maximum slope methods.
MedLine Citation:
PMID:  19616910     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: We investigated whether the prerequisite of the maximum slope and deconvolution methods are satisfied in pancreatic perfusion CT and whether the measured parameters between these algorithms are correlated.
METHODS: We examined nine beagles injected with iohexol (200mgIkg(-1)) at 5.0mls(-1). The abdominal aorta and splenic and celiac arteries were selected as the input arteries and the splenic vein, the output veins. For the maximum slope method, we determined the arterial contrast volume of each artery by measuring the area under the curve (AUC) and compared the peak enhancement time in the pancreas with the contrast appearance time in the splenic vein. For the deconvolution method, the artery-to-vein collection rate of contrast medium was calculated. We calculated the pancreatic tissue blood flow (TBF), tissue blood volume (TBV), and mean transit time (MTT) using both algorithms and investigated their correlation based on vessel selection.
RESULTS: The artery AUC significantly decreased as it neared the pancreas (P<0.01). In all cases, the peak time of the pancreas (11.5±1.6) was shorter than the appearance time (14.1±1.6) in the splenic vein. The splenic artery-vein combination exhibited the highest collection rate (91.1%) and was the only combination that was significantly correlated between TBF, TBV, and MTT in both algorithms.
CONCLUSION: Selection of a vessel nearest to the pancreas is considered as a more appropriate prerequisite. Therefore, vessel selection is important in comparison of the semi-quantitative parameters obtained by different algorithms.
Miori Kishimoto; Yoshihisa Tsuji; Nana Katabami; Junichiro Shimizu; Ki-Ja Lee; Toshiroh Iwasaki; Yoh-Ichi Miyake; Shujiro Yazumi; Tsutomu Chiba; Kazutaka Yamada
Publication Detail:
Type:  Journal Article     Date:  2009-07-18
Journal Detail:
Title:  European journal of radiology     Volume:  77     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  175-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-11 Inada-cho, Obihiro 080-8555, Japan.
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