| Measurement of brain perfusion, blood volume, and blood-brain barrier permeability, using dynamic contrast-enhanced T(1)-weighted MRI at 3 tesla. | |
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MedLine Citation:
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PMID: 19780145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Assessment of vascular properties is essential to diagnosis and follow-up and basic understanding of pathogenesis in brain tumors. In this study, a procedure is presented that allows concurrent estimation of cerebral perfusion, blood volume, and blood-brain permeability from dynamic T(1)-weighted imaging of a bolus of a paramagnetic contrast agent passing through the brain. The methods are applied in patients with brain tumors and in healthy subjects. Perfusion was estimated by model-free deconvolution using Tikhonov's method (gray matter/white matter/tumor: 72 +/- 16/30 +/- 8/56 +/- 45 mL/100 g/min); blood volume (6 +/- 2/4 +/- 1/7 +/- 6 mL/100 g) and permeability (0.9 +/- 0.4/0.8 +/- 0.3/3 +/- 5 mL/100 g/min) were estimated by using Patlak's method and a two-compartment model. A corroboration of these results was achieved by using model simulation. In addition, it was possible to generate maps on a pixel-by-pixel basis of cerebral perfusion, cerebral blood volume, and blood-brain barrier permeability. |
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Authors:
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Henrik B W Larsson; Fr??d??ric Courivaud; Egill Rostrup; Adam E Hansen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 62 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-03 Completed Date: 2010-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1270-81 Citation Subset: IM |
Copyright Information:
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(c) 2009 Wiley-Liss, Inc. |
Affiliation:
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Functional Imaging Unit, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark. henlar02@glo.regionh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Blood Volume* Blood-Brain Barrier / pathology, physiopathology* Brain / blood supply, pathology, physiopathology* Brain Neoplasms / pathology, physiopathology* Cerebrovascular Circulation* Computer Simulation Female Humans Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Male Middle Aged Models, Biological Perfusion Imaging / methods* Permeability |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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