| Measurement of blood flow and vascular permeability changes in response to 12-O-tetradecanoyl-phorbol-13-acetate and to asbestos fibers. | |
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MedLine Citation:
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PMID: 7328704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hyperemia (increased blood flow) and vascular permeability changes induced in rabbit skin by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate and by asbestos fibers have been quantitated. The resultant hyperemia, measured with radiolabeled microspheres, was inhibited in both cases by steroidal and nonsteroidal anti-inflammatory drugs. Since the inflammatory responses resulting from exposure to these agents might be important for the subsequent development of neoplasms, it is proposed that such a specific and quantitative technique be used to analyze the components of these inflammatory responses in more detail. |
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Authors:
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J A Hamilton; P Vadas; J B Hay |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of toxicology and environmental health Volume: 8 ISSN: 0098-4108 ISO Abbreviation: J Toxicol Environ Health Publication Date: 1981 Jul-Aug |
Date Detail:
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Created Date: 1982-04-20 Completed Date: 1982-04-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513622 Medline TA: J Toxicol Environ Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 205-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Anti-Inflammatory Agents / pharmacology Asbestos / adverse effects* Capillary Permeability / drug effects* Hyperemia / chemically induced, etiology* Kinetics Phorbols / toxicity* Rabbits Tetradecanoylphorbol Acetate / toxicity* |
| Grant Support | |
ID/Acronym/Agency:
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CA-08748/CA/NCI NIH HHS; ES-02014-01/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Phorbols; 1332-21-4/Asbestos; 16561-29-8/Tetradecanoylphorbol Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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