Document Detail


Measurement of blood flow and vascular permeability changes in response to 12-O-tetradecanoyl-phorbol-13-acetate and to asbestos fibers.
MedLine Citation:
PMID:  7328704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hyperemia (increased blood flow) and vascular permeability changes induced in rabbit skin by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate and by asbestos fibers have been quantitated. The resultant hyperemia, measured with radiolabeled microspheres, was inhibited in both cases by steroidal and nonsteroidal anti-inflammatory drugs. Since the inflammatory responses resulting from exposure to these agents might be important for the subsequent development of neoplasms, it is proposed that such a specific and quantitative technique be used to analyze the components of these inflammatory responses in more detail.
Authors:
J A Hamilton; P Vadas; J B Hay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of toxicology and environmental health     Volume:  8     ISSN:  0098-4108     ISO Abbreviation:  J Toxicol Environ Health     Publication Date:    1981 Jul-Aug
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7513622     Medline TA:  J Toxicol Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Animals
Anti-Inflammatory Agents / pharmacology
Asbestos / adverse effects*
Capillary Permeability / drug effects*
Hyperemia / chemically induced,  etiology*
Kinetics
Phorbols / toxicity*
Rabbits
Tetradecanoylphorbol Acetate / toxicity*
Grant Support
ID/Acronym/Agency:
CA-08748/CA/NCI NIH HHS; ES-02014-01/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Phorbols; 1332-21-4/Asbestos; 16561-29-8/Tetradecanoylphorbol Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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