| Measurement of blood coagulation with considering RBC aggregation through a microchip-based light transmission aggregometer. | |
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MedLine Citation:
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PMID: 21498900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Even though blood coagulation can be tested by various methods and techniques, the effect of RBC aggregation on blood coagulation is not fully understood. The present study monitored clot formation in a microchip-based light transmission aggregometer. Citrated blood samples with and without the addition of calcium ion solution were initially disaggregated by rotating a stirrer in the microchip. After abrupt stop of the rotating stirrer, the transmitted light intensity over time was recorded. The syllectogram (light intensity vs. time graph) manifested a rapid increase that is associated with RBC aggregation followed by a decrease that is associated with blood coagulation. The time to reach the peak point was used as a new index of coagulation time (CT) and ranged from 200 to 500 seconds in the present measurements. The CT was inversely proportional to the concentration of fibrinogen, which enhances RBC aggregation. In addition, the CT was inversely proportional to the hematocrit, which is similar to the case of the prothrombin time (PT), as measured by a commercial coagulometer. Thus, we carefully concluded that RBC aggregation should be considered in tests of blood coagulation. |
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Authors:
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Hyunjung Lim; Jeonghun Nam; Shubin Xue; Sehyun Shin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical hemorheology and microcirculation Volume: 47 ISSN: 1875-8622 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-08-11 Revised Date: 2011-10-07 |
Medline Journal Info:
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Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
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Languages: eng Pagination: 211-8 Citation Subset: IM |
Affiliation:
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School of Mechanical Engineering, Korea University, Seoul, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Coagulation* Erythrocyte Aggregation* Erythrocytes / chemistry, cytology* Female Humans Light Male Microarray Analysis / instrumentation, methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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