Document Detail

Measurement of atrial volumes by magnetic resonance imaging in healthy volunteers and in patients with myocardial infarction.
MedLine Citation:
PMID:  7737206     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance imaging was used to measure atrial volumes and emptying fractions in healthy volunteers to establish normal ranges and also in patients with myocardial infarction. Fourteen healthy volunteers (age mean +/- SD, 47 +/- 13 years) and 14 patients (age 56 +/- 9) with previous myocardial infarction were studied. All patients were in sinus rhythm, had competent cardiac valves and no heart failure. Atrial and ventricular volumes were measured from a set of cardiac gated transverse spin echo images (TE 40 ms) covering the heart and acquired at the end of ventricular systole and diastole. Ventricular ejection fractions and atrial emptying fractions were calculated. In patients with myocardial infarction, left atrial end-diastolic and systolic volumes were significantly higher (P < 0.001), and the emptying fraction significantly lower (P < 0.001) than in the control group. The right atrial end-diastolic volume was also significantly higher (P < 0.05) and the emptying fraction significantly lower (P < 0.01) than those in the control group. These findings are likely to be due to abnormal left ventricular long axis dynamics caused by damage to the myocardium, and reflect the abnormal systolic and diastolic functions of the left ventricle which contribute to atrial filling and emptying, respectively. Changes in atrial volumes can be measured non-invasively by magnetic resonance imaging. Using this method we have studied the normal ranges and demonstrated abnormalities in patients with myocardial infarction. Thus this imaging method may prove to be useful for studying atrial function under different physiological and pathological conditions and for evaluating the effect of therapeutic interventions on atrial function.
R H Mohiaddin; M Hasegawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  16     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  106-11     Citation Subset:  IM    
Magnetic Resonance Unit, Royal Brompton Hospital, London, U.K.
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MeSH Terms
Atrial Function / physiology*
Magnetic Resonance Imaging*
Middle Aged
Myocardial Infarction / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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