Document Detail


Measurement of arterial input function of 17O water tracer in rat carotid artery by using a region-defined (REDE) implanted vascular RF coil.
MedLine Citation:
PMID:  12845538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A method of determining arterial input function (AIF) by continuously detecting the (17)O MR signal changes of (17)O-labeled water tracer in the rat carotid artery using a region-defined (REDE) implanted vascular RF coil at 9.4 Tesla is reported. This coil has a compact physical size of 1 mm inner diameter, 3 mm outer diameter and 11 mm in length. It can be readily implanted into the rat neck and wrapped around the rat carotid artery for achieving adequate MR detection sensitivity for determining AIF with minimal surgical trauma. Water phantom and in vivo MR experiments were conducted for validating the coil's performance. A signal-to-noise ratio of approximately 20:1 was achieved for the (17)O signal acquired from naturally abundant H(2)(17)O in a small amount of blood (approximately 7 microl) inside the rat carotid artery with an acquisition time of 11 s. The REDE RF coil design electromagnetically isolates the rat carotid artery from surrounding tissues and ensures that the MR signal detected by the RF coil is only attributable to the artery blood. It also minimizes the electromagnetic coupling between the implanted RF coil and a head surface coil tuned at the same operating frequency (two-coil configuration). This configuration allowed simultaneous measurements of dynamic changes of (17)O MR signal of the H(2)(17)O tracer in both rat carotid artery and brain. Compared to most contemporary MR approaches, the REDE implanted RF provides a simple, accurate, and promising solution for determination of AIF in small experimental animals.
Authors:
Xiaoliang Zhang; Xiao-Hong Zhu; Runxia Tian; Yi Zhang; Hellmut Merkle; Wei Chen
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Validation Studies     Date:  2003-07-04
Journal Detail:
Title:  Magma (New York, N.Y.)     Volume:  16     ISSN:  0968-5243     ISO Abbreviation:  MAGMA     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-08-15     Completed Date:  2004-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9310752     Medline TA:  MAGMA     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  77-85     Citation Subset:  IM    
Affiliation:
Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S.E., Department of Radiology, Minneapolis, Minnesota, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Brain / blood supply*,  metabolism*
Carotid Arteries / physiology*
Cerebrovascular Circulation / physiology
Magnetic Resonance Imaging / instrumentation*,  methods
Magnetics / diagnostic use,  instrumentation
Male
Oxygen / metabolism*
Oxygen Isotopes*
Radioisotope Dilution Technique*
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Sensitivity and Specificity
Transducers*
Water
Grant Support
ID/Acronym/Agency:
EB00329/EB/NIBIB NIH HHS; NS38070/NS/NINDS NIH HHS; NS39043/NS/NINDS NIH HHS; NS41262/NS/NINDS NIH HHS; P41 RR08079/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Oxygen Isotopes; 7732-18-5/Water; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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