Document Detail


Measurement of anesthetics in blood using a conventional infrared clinical gas analyzer.
MedLine Citation:
PMID:  17717223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Measurement of the partial pressure of volatile anesthetics in blood is usually done using a "headspace equilibration" method with gas chromatography. However, it is not often performed in clinical studies because of the technical, equipment, and logistic requirements. To improve the accessibility of this measurement, we tested the use of a common infrared clinical gas analyzer, the Datex-Ohmeda Capnomac, for this purpose. METHODS: After characterization of the linearity of the device in measuring the volatile anesthetic concentration in the presence of nitrous oxide, carbon dioxide, and water vapor, blood was tonometered with known concentrations of sevoflurane (actual value between 0.5% and 5.0%) in oxygen and oxygen/nitrous oxide mixtures, as well as mixtures of isoflurane and desflurane in oxygen. RESULTS: Mean bias (standard deviation) overall for sevoflurane in oxygen relative to the tonometered reference partial pressure was -4.5 (4.8%) of the actual concentration. This was not altered significantly by measurement in 40% oxygen/60% nitrous oxide. For isoflurane and desflurane it was -3.9 (3.3%) and -4.6 (3.8%), respectively, of the actual concentration. CONCLUSIONS: The accuracy and precision of measurement of volatile anesthetic gas partial pressures in blood by a double headspace equilibration technique, using a clinical infrared gas analyzer, were comparable to that achieved by previous studies using gas chromatography.
Authors:
Philip J Peyton; Michael Chong; Christopher Stuart-Andrews; Gavin J B Robinson; Robert Pierce; Bruce R Thompson
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  105     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-24     Completed Date:  2007-09-18     Revised Date:  2007-12-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  680-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Anaesthesia, Austin Hospital, and University of Melbourne, Melbourne, Australia. phil.peyton@austin.org.au
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Inhalation / instrumentation*
Anesthetics, Combined / blood*
Anesthetics, Inhalation / blood*
Carbon Dioxide / blood
Chromatography, Gas
Humans
Isoflurane / analogs & derivatives*,  blood*
Manometry
Methyl Ethers / blood*
Models, Biological
Nitrous Oxide / blood
Oxygen / blood
Partial Pressure
Reproducibility of Results
Spectrophotometry, Infrared / instrumentation*
Time Factors
Volatilization
Water / analysis
Chemical
Reg. No./Substance:
0/Anesthetics, Combined; 0/Anesthetics, Inhalation; 0/Methyl Ethers; 10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 57041-67-5/desflurane; 7732-18-5/Water; 7782-44-7/Oxygen
Comments/Corrections
Comment In:
Anesth Analg. 2007 Dec;105(6):1869   [PMID:  18042906 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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