| Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 T. | |
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MedLine Citation:
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PMID: 20597122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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N-Acetylaspartylglutamate in human brain has been measured with difference editing at 7 T. The CH(2) proton resonances (∼ 2.5 ppm) of the aspartyl groups of N-acetylaspartylglutamate and N-acetylaspartate were difference edited (MEGA) using 20-msec gaussian radiofrequency pulses for selective 180 ° rotations of the coupling partners at 4.61 and 4.38 ppm, respectively. The echo time of the editing sequence, 108 msec, was obtained in phantom tests. Single-voxel localized in vivo measurements were conducted in the medial prefrontal and right frontal cortices of five healthy volunteers. The gray and white matter fractions within the voxels were obtained from T(1)-weighted image segmentation. Using linear regression of the metabolite concentration vs. fractional white matter contents within the voxels, the N-acetylaspartylglutamate-to-N-acetylaspartate concentration ratios in gray and white matter were estimated to be 0.13 and 0.28 by difference editing (95% confidence intervals 0.07-0.19 and 0.22-0.34), respectively, assuming identical relaxation effects between the metabolites. |
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Authors:
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Changho Choi; Subroto Ghose; Jinsoo Uh; Aditya Patel; Ivan E Dimitrov; Hanzhang Lu; Deborah Douglas; Sandeep Ganji |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-28 Completed Date: 2011-03-08 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1247-51 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. |
Affiliation:
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Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. changho.choi@utsouthwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms* Dipeptides / analysis* Female Frontal Lobe / chemistry* Humans Magnetic Resonance Spectroscopy / methods* Male Protons / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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P41 RR002584-22/RR/NCRR NIH HHS; P41 RR002584-23/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dipeptides; 0/Protons; 3106-85-2/N-acetyl-1-aspartylglutamic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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