| Measurement of MRI enhancement kinetics for evaluation of inflammatory activity in Crohn's disease. | |
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MedLine Citation:
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PMID: 20122516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the feasibility of determining local inflammatory activity of Crohn's disease by measurement of bowel wall perfusion kinetics using contrast-enhanced magnetic resonance imaging (MRI). MATERIAL AND METHODS: Twenty-six patients with histologically proven Crohn's disease who underwent magnetic resonance (MR) enteroclysis at 1.5 T were included in this retrospective study. Over 109 s, 150 images were acquired with a fat-saturated coronal T1-weighted 2D gradient echo sequence (TR, 9 ms; TE, 1.5 ms) during intravenous contrast administration by means of a pump (Magnevist, 0.2 ml/kg, flow 3 ml/s). On each image, signal intensity was measured in a region of interest placed in an area of maximum thickening of the inflamed bowel wall. Enhancement kinetics were correlated with the endoscopically determined severity of inflammatory activity (on a scale of 0-3). RESULTS: The slope of the contrast enhancement curve significantly correlated with local inflammatory activity determined by endoscopy (R=0.594, P=.007). No significant correlation was found for area under the curve and peak maximum (R=0.411, P=.08 and R=0.334, P=.15, respectively). CONCLUSION: Determination of the perfusion kinetics of the bowel wall by MRI enables quantitative evaluation of local inflammatory activity in patients with Crohn's disease. |
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Authors:
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Rainer R?ttgen; Thomas Grandke; Christian Grieser; Lukas Lehmkuhl; Bernd Hamm; Lutz L?demann |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Clinical imaging Volume: 34 ISSN: 1873-4499 ISO Abbreviation: Clin Imaging Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8911831 Medline TA: Clin Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 29-35 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Klinik f?r Strahlenheilkunde, Charit? Campus Virchow-Klinikum, Universit?tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. rainer.roettgen@charite.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Computer Simulation Contrast Media / pharmacokinetics Crohn Disease / complications, diagnosis*, metabolism* Feasibility Studies Female Gadolinium DTPA / diagnostic use*, pharmacokinetics* Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods Inflammation / complications, diagnosis*, metabolism* Kinetics Magnetic Resonance Imaging / methods* Male Metabolic Clearance Rate Models, Biological Perfusion Imaging / methods Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
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