| Measurement of Glucose Area Under the Curve Using Minimally Invasive Interstitial Fluid Extraction Technology: Evaluation of Glucose Monitoring Concepts Without Blood Sampling. | |
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MedLine Citation:
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PMID: 21770766 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Background: Monitoring postprandial hyperglycemia is crucial in treating diabetes, although its dynamics make accurate monitoring difficult. We developed a new technology for monitoring postprandial hyperglycemia using interstitial fluid (ISF) extraction technology without blood sampling. The glucose area under the curve (AUC) using this system was measured as accumulated ISF glucose (IG) with simultaneous calibration with sodium ions. The objective of this study was to evaluate this technological concept in healthy individuals. Methods: Minimally invasive ISF extraction technology (MIET) comprises two steps: pretreatment with microneedles and ISF accumulation over a specific time by contact with a solvent. The correlation between glucose and sodium ion levels using MIET was evaluated in 12 subjects with stable blood glucose (BG) levels during fasting. BG and IG time courses were evaluated in three subjects to confirm their relationship while BG was fluctuating. Furthermore, the accuracy of glucose AUC measurements by MIET was evaluated several hours after a meal in 30 subjects. Results: A high correlation was observed between glucose and sodium ion levels when BG levels were stable (R=0.87), indicating that sodium ion is a good internal standard for calibration. The variation in IG and BG with MIET was similar, indicating that IG is an adequate substitute for BG. Finally, we showed a strong correlation (R=0.92) between IG-AUC and BG-AUC after a meal. Conclusions: These findings validate the adequacy of glucose AUC measurements using MIET. Monitoring glucose using MIET without blood sampling may be beneficial to patients with diabetes. |
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Authors:
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Toshiyuki Sato; Seiki Okada; Kei Hagino; Yoshihiro Asakura; Yasuo Kikkawa; Junko Kojima; Toshihiro Watanabe; Yasunori Maekawa; Kazuki Isobe; Reona Koike; Hiromu Nakajima; Kaoru Asano |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-19 |
Journal Detail:
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Title: Diabetes technology & therapeutics Volume: - ISSN: 1557-8593 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Central Research Laboratories , Sysmex Corporation, Kobe, Japan . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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