Document Detail


Measurement of Fetal Fat in Utero in Normal and Diabetic Pregnancy using Magnetic Resonance Imaging.
MedLine Citation:
PMID:  23288811     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives We have developed and assessed the reliability of magnetic resonance (MR) imaging techniques to measure fetal fat volume in utero. We studied fetal growth in women with and without diabetes in view of the increased prevalence of macrosomia in the former. Methods We studied 26 pregnant women, 14 with pre-gestational diabetes and 12 controls. Fetal assessments took place at 24 weeks and again at 34 weeks gestation by standard ultrasound biometry assessment followed by MR imaging at 1.5 T. Fetal fat volume was determined from T1 weighted water suppressed images using a semi-automated approach based upon pixel intensity and taking account of partial volume effects. Fetal volume was also determined from the MR images. Fetal weight was calculated using published fat and lean tissue densities. Results There was little fetal fat at 24 weeks gestation but at 34 weeks, fetal fat content was considerable and greater in the women with diabetes at mean (SD) 1090 (417) cm(3) compared with 541 (348) cm(3) in controls (p = 0.006). Measurements of fetal fat volume showed low intra- and inter-observer variability at 34 weeks with intra-class correlation co-efficients consistently above 0.99. Birth weight centile correlated with fetal fat volume (R(2) = 0.496, p = 0.001), percentage fetal fat (R(2) = 0.362, p = 0.008) and calculated fetal weight (R(2) = 0.492, p < 0.001) at 34 weeks. Conclusions MR imaging appears a promising tool for the determination of fetal fat, body composition and weight in utero in the third trimester of pregnancy.Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
Devasuda Anblagan; Ruta Deshpande; Nia W Jones; Carolyn Costigan; George Bugg; Nick Raine Fenning; Penny A Gowland; Peter Mansell
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham.
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