Document Detail

Measurement of Endotoxins in Bioaerosols at Workplace: A Critical Review of Literature and a Standardization Issue.
MedLine Citation:
PMID:  23002277     Owner:  NLM     Status:  Publisher    
Endotoxins are lipopolysaccharides found in the outer membrane of most Gram-negative bacteria and cyanobacteria. Worker exposure to endotoxins has been shown in a number of work situations and is associated with both respiratory and systemic pathologies. The lack of an occupational exposure limit is mainly due to the absence of a standard protocol at the international level for sampling and analyzing airborne endotoxins. The bibliographic review in this article takes an exhaustive look at the current knowledge on measuring airborne endotoxins. It shows that, despite several reference documents at the international level, the methods used to measure endotoxin exposure differ considerably from one laboratory to another. Standardization is necessary to reduce interlaboratory variability and, ultimately, to improve the use of interstudy data. The bibliographic review presents the current status of standardization for airborne endotoxin measurement methods in the workplace and summarizes areas for further research. This article is both a reference document for all operators wishing to use such methods and a working document to build international consensus around the measurement of airborne endotoxins.
Philippe Duquenne; Geneviève Marchand; Caroline Duchaine
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-20
Journal Detail:
Title:  The Annals of occupational hygiene     Volume:  -     ISSN:  1475-3162     ISO Abbreviation:  Ann Occup Hyg     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203526     Medline TA:  Ann Occup Hyg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratoire de Métrologie des Aérosols, Institut National de Recherche et de Sécurité , Vandoeuvre-Les-Nancy , France;
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