| The Measurement of Endogenous Carbon Monoxide Production. | |
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MedLine Citation:
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PMID: 22442030 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Recent findings that heme oxygenase-1 can be induced by oxidative stress and inflammation in many different cellular systems and that carbon monoxide (CO) produced as a byproduct of this enzyme is a signaling molecule, have generated a major research area with hundreds of studies published over the last few years. The measurement of expired CO concentration has been used in humans as a biomarker of induced heme oxygenase resulting from inflammation or oxidative stress, but a precise method of measuring endogenous CO production that can be easily used to study patients is needed. The present study describes such a method. The described method allows calculation of the rate of heme catabolism with a precision of ± 2 µmoles/hour, approximately 10% of the mean normal rate in subjects used in this investigation. This method which is subject-patient-friendly, precise and inexpensive to perform should be applicable to studies performed on humans with induced heme oxygenase and studies of effects of therapy for inflammatory and hemolytic diseases. |
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Authors:
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Ronald F Coburn |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-22 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Pennsylvania School of Medicine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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