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Measurement of CSF dynamics with oscillating pressure infusion.
MedLine Citation:
PMID:  23278837     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Infusion tests are used to diagnose and select patients with idiopathic normal pressure hydrocephalus (INPH) for shunt surgery. The test characterizes cerebrospinal fluid dynamics and estimates parameters of the cerebrospinal fluid system, the pressure-volume index (PVI) and the outflow conductance (C(out) ). The Oscillating Pressure Infusion (OPI) method was developed to improve the test and reduce the investigation time. The aim of this study was to evaluate the new OPI method by comparing it with an established reference method. METHODS: Forty-seven patients (age 71.2 ± 8.9 years) with communicating hydrocephalus underwent a preoperative lumbar infusion investigation with two consecutive infusion protocols, reference (42 min) and new (20 min), that is, 94 infusion tests in total. The OPI method estimated C(out) and PVI simultaneously. A real-time analysis of reliability was applied to investigate the possibility of infusion time reduction. RESULTS: The difference in C(out) between the methods was 1.2 ± 1.8 μl/s/kPa (ΔR(out ) = -0.8 ± 3.5 mmHg/ml/min), P < 0.05, n = 47. With the reliability analysis, the preset 20 min of active infusion could have been even further reduced for 19 patients to between 10 and 19 min. PVI was estimated to 16.1 ± 6.9 ml, n = 47. CONCLUSIONS: The novel Oscillating Pressure Infusion method produced real-time estimates of C(out) including estimates of reliability that was in good agreement with the reference method and allows for a reduced and individualized investigation time.
Authors:
K Andersson; I R Manchester; K Laurell; K Giuliana Cesarini; J Malm; A Eklund
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-28
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  -     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden.
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