Document Detail

Measurement of blood flow in arteriovenous malformations before and after embolization using arterial spin labeling.
MedLine Citation:
PMID:  22440600     Owner:  NLM     Status:  MEDLINE    
The assessment of shunt reduction after an embolization of an arteriovenous malformation (AVM) or fistula (AVF) from conventional angiography is often difficult and may be subjective. Here we present a completely non-invasive method using magnetic resonance imaging (MRI) to measure shunt reduction. Using pulsed arterial spin labeling (PASL), we determined the relative amount of signal attributed to the shunt over 1.75 s and 6 different slices covering the lesion. This amount of signal from the shunt was related to the total signal from all slices and measured before and after embolization. The method showed a fair agreement between the PASL results and the judgement from conventional angiography. In the case of a total or subtotal shunt occlusion, PASL showed a shunt reduction between 69% and 92%, whereas in minimal shunt reduction as judged by conventional angiography, the ASL result was -6% (indicating slightly increased flow) to 35% in a partially occluded vein of Galen aneurysm. The PASL method proved to be fairly reproducible (up to 2% deviation between three measurements without interventions). On conclusion, PASL is able to reliably measure the amount of shunt reduction achieved by embolization of AVMs and AVFs.
L Suazo; B Foerster; R Fermin; H Speckter; C Vilchez; J Oviedo; P Stoeter
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2012-03-16
Journal Detail:
Title:  Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences     Volume:  18     ISSN:  1591-0199     ISO Abbreviation:  Interv Neuroradiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-23     Completed Date:  2012-05-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9602695     Medline TA:  Interv Neuroradiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  42-8     Citation Subset:  IM    
CEDIMAT, Plaza de la Salud, Santo Domingo, Republica Dominicana.
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MeSH Terms
Cerebrovascular Circulation / physiology*
Embolization, Therapeutic*
Intracranial Arteriovenous Malformations / pathology*,  physiopathology,  therapy*
Magnetic Resonance Angiography / methods*,  standards
Prospective Studies
Reproducibility of Results
Spin Labels*
Treatment Outcome
Reg. No./Substance:
0/Spin Labels

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