| [Measurement of 75Se-SeHCAT abdominal retention in the initial diagnosis of Bile Acid Absorption (BAM)]. | |
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MedLine Citation:
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PMID: 21524824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the usefulness of the (75)SeHCAT abdominal retention (AR) measurement in the early diagnosis of diarrhea syndrome (DS). METHODS: Thirty-seven patients with diarrhea syndrome within the first month of evolution were prospectively evaluated. The (75)Se-SeHCAT abdominal retention was measured 4 and 7 days post-administration of 0.01 mCi of (75)SeHCAT. The test was performed prior to treatment and at 3 months when the baseline study was positive. The test was considered positive if the RA was <25% at 4(th) and <10% on the 7th day. The patients were visited at 3 months. Depending on the response, 3 groups were established: a) complete response: normalization of stool frequency, b) partial response, decrease of frequency or c) no response. RESULTS: Group A: The AR of (75)Se-SEHCAT was normal in 21 patients. Six were diagnosed of colonic diverticulosis, 8 of irritable bowel syndrome, 1 of lymphocytic colitis, 1 of post-gastroenteritis syndrome, 1 of celiac disease and 1 of stenosis of the cardia. Four are still under study. Group B: The AR of (75)Se-SEHCAT decreased in 16 patients. All showed abnormal AR at day 7 and all but 1 at day 4. Following administration of cholestyramine resin, 8 (50%) presented partial response and 8 (50%) complete response. At 3 months, AR had increased at day 4 and 9 at day 7. CONCLUSION: The measurement of (75)SEHCAT abdominal retention allows the early diagnosis of bile acid malabsorption in 43% of the patients with DS. Measurement at 7 days seems more accurate than that at 4 days. |
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Authors:
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P C Notta; D Ramal; S Maisterra; A Rodríguez Gasen; S Maymó; A Sabaté; A Girbau; J Guardiola; J Martín-Comín |
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Publication Detail:
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Type: Clinical Trial; English Abstract; Journal Article Date: 2011-04-27 |
Journal Detail:
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Title: Revista española de medicina nuclear Volume: 30 ISSN: 1578-200X ISO Abbreviation: Rev Esp Med Nucl Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-08-29 Completed Date: 2012-01-05 Revised Date: 2012-10-08 |
Medline Journal Info:
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Nlm Unique ID: 9208726 Medline TA: Rev Esp Med Nucl Country: Spain |
Other Details:
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Languages: spa Pagination: 297-300 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier España, S.L. y SEMNIM. All rights reserved. |
Affiliation:
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Servicio de Medicina Nuclear y Servicio de Gastroenterología, Hospital Universitari de Bellvitge, Idibell, Hospitalet de Llobregat, Barcelona, España. |
Vernacular Title:
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Medición de la absorción de los ácidos biliares en el diagnóstico inicial de la diarrea crónica. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen
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radionuclide imaging Adult Aged Aged, 80 and over Anticholesteremic Agents / therapeutic use Cardia / pathology Celiac Disease / complications, diagnosis Cholestyramine Resin / therapeutic use Chronic Disease Colitis, Lymphocytic / complications, diagnosis Constriction, Pathologic Diarrhea / diagnosis, drug therapy, etiology, metabolism, radionuclide imaging* Diverticulosis, Colonic / complications, diagnosis Early Diagnosis Female Humans Intestinal Absorption Irritable Bowel Syndrome / complications, diagnosis Malabsorption Syndromes / etiology, radionuclide imaging* Male Middle Aged Prospective Studies Radiopharmaceuticals / diagnostic use*, pharmacokinetics Selenium Radioisotopes / diagnostic use*, pharmacokinetics Taurocholic Acid / analogs & derivatives*, diagnostic use, pharmacokinetics Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Radiopharmaceuticals; 0/Selenium Radioisotopes; 11041-12-6/Cholestyramine Resin; 75018-70-1/23-seleno-25-homotaurocholic acid; 81-24-3/Taurocholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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