| Measurement of 5-hydroxy-2-aminovaleric acid as a specific marker of metal catalysed oxidation of proline and arginine residues of low density lipoprotein apolipoprotein B-100 in human atherosclerotic lesions. | |
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MedLine Citation:
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PMID: 12890816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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gamma-Glutamyl-semialdehyde (gammaGSA) is a major product of the metal catalysed oxidation of apolipoprotein B-100 (apoB-100) proline and arginine residues. On reduction, gammaGSA forms 5-hydroxy-2-aminovaleric acid (HAVA). This report describes the application of HAVA measurement to characterise the formation of gammaGSA in low density lipoprotein (LDL) recovered from human atherosclerotic lesions. HAVA concentrations were greatly increased in LDL from early (mean, 10.25; SD, 3.49 mol/mol apoB-100; p < 0.01), intermediate (mean, 11.18; SD, 2.37 mol/mol apoB-100; p < 0.01), and advanced (mean, 9.91; SD, 2.15 mol/mol apoB-100; p < 0.01) lesions, when compared with LDL from normal aortic tissue (mean, 0.05; SD, 0.01 mol/mol apoB-100). These findings support the hypothesis that pathways involving metal catalysed oxidation of LDL apoB-100 are of pathological importance in atherogenesis. |
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Authors:
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J Pietzsch; R Bergmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 56 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-31 Completed Date: 2003-09-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: England |
Other Details:
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Languages: eng Pagination: 622-3 Citation Subset: AIM; IM |
Affiliation:
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Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, PO Box 510119, D-01314 Dresden, Germany. j.pietzsch@fz-rossendorf.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / analysis* Aorta, Thoracic Apolipoprotein B-100 Apolipoproteins B / metabolism* Arginine / metabolism* Arteriosclerosis / metabolism* Biological Markers / analysis Catalysis Glutamates / metabolism Humans Lipoproteins, LDL / metabolism Male Metals / metabolism Middle Aged Oxidation-Reduction Proline / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Apolipoprotein B-100; 0/Apolipoproteins B; 0/Biological Markers; 0/Glutamates; 0/Lipoproteins, LDL; 0/Metals; 147-85-3/Proline; 496-92-4/glutamic acid gamma-semialdehyde; 533-88-0/2-amino-5-hydroxyvaleric acid; 74-79-3/Arginine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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