Document Detail

Measurement of 5-hydroxy-2-aminovaleric acid as a specific marker of metal catalysed oxidation of proline and arginine residues of low density lipoprotein apolipoprotein B-100 in human atherosclerotic lesions.
MedLine Citation:
PMID:  12890816     Owner:  NLM     Status:  MEDLINE    
gamma-Glutamyl-semialdehyde (gammaGSA) is a major product of the metal catalysed oxidation of apolipoprotein B-100 (apoB-100) proline and arginine residues. On reduction, gammaGSA forms 5-hydroxy-2-aminovaleric acid (HAVA). This report describes the application of HAVA measurement to characterise the formation of gammaGSA in low density lipoprotein (LDL) recovered from human atherosclerotic lesions. HAVA concentrations were greatly increased in LDL from early (mean, 10.25; SD, 3.49 mol/mol apoB-100; p < 0.01), intermediate (mean, 11.18; SD, 2.37 mol/mol apoB-100; p < 0.01), and advanced (mean, 9.91; SD, 2.15 mol/mol apoB-100; p < 0.01) lesions, when compared with LDL from normal aortic tissue (mean, 0.05; SD, 0.01 mol/mol apoB-100). These findings support the hypothesis that pathways involving metal catalysed oxidation of LDL apoB-100 are of pathological importance in atherogenesis.
J Pietzsch; R Bergmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  56     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-31     Completed Date:  2003-09-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  622-3     Citation Subset:  AIM; IM    
Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, PO Box 510119, D-01314 Dresden, Germany.
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MeSH Terms
Amino Acids / analysis*
Aorta, Thoracic
Apolipoprotein B-100
Apolipoproteins B / metabolism*
Arginine / metabolism*
Arteriosclerosis / metabolism*
Biological Markers / analysis
Glutamates / metabolism
Lipoproteins, LDL / metabolism
Metals / metabolism
Middle Aged
Proline / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Apolipoprotein B-100; 0/Apolipoproteins B; 0/Biological Markers; 0/Glutamates; 0/Lipoproteins, LDL; 0/Metals; 147-85-3/Proline; 496-92-4/glutamic acid gamma-semialdehyde; 533-88-0/2-amino-5-hydroxyvaleric acid; 74-79-3/Arginine

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