Document Detail

Measured and modeled personal exposures to and risks from volatile organic compounds.
MedLine Citation:
PMID:  18200885     Owner:  NLM     Status:  MEDLINE    
We developed a personal exposure model using volatile organic compound data collected for teachers and office workers as part of the Boston Exposure Assessment in Microenvironments (BEAM) study. We included participant-specific time-activity and concentration measurements of residential outdoor, residential indoor, and workplace microenvironments, along with average concentrations in various dining, retail, and transportation microenvironments. We used a series of time-weighted personal exposure models to compare measured personal concentrations using median regression models, with bias estimates representing the difference between measured and modeled personal exposures. Incorporating only the outdoor microenvironment results in an unbiased estimate of personal exposure only for carbon tetrachloride. Adding the residential indoor microenvironment provides an unbiased estimate for trichloroethene as well. A model incorporating residential outdoor, indoor, and workplace microenvironments provides an unbiased estimate for the above compounds and chloroform, 1,4-dichlorobenzene, benzene, and alpha-pinene, and adding the transportation microenvironment adds ethylbenzene. A fully saturated model, including outdoor, indoor, workplace, transportation, and all other microenvironments, provides an unbiased estimate for the previously listed compounds along with tetrachloroethene and styrene. MTBE, toluene, o-xylene, d-limonene, formaldehyde, and acetaldehyde were not fully characterized even in the saturated model, emphasizing that additional time-activity and concentration information would more fully characterize personal exposure.
Robin E Dodson; E Andres Houseman; Jonathan I Levy; John D Spengler; James P Shine; Deborah H Bennett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental science & technology     Volume:  41     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8498-505     Citation Subset:  IM    
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
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MeSH Terms
Environmental Exposure
Models, Theoretical*
Occupational Exposure
Organic Chemicals / toxicity*
Risk Factors
Grant Support
Reg. No./Substance:
0/Organic Chemicals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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