| Measure of the QT-RR Dynamic Coupling in Patients with the Long QT Syndrome. | |
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MedLine Citation:
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PMID: 23094878 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: The patients with the long QT syndrome type-1 (LQT-1) have an impaired adaptation of the QT interval to heart rate changes. Yet, the description of the dynamic QT-RR coupling in genotyped LQT-1 has never been thoroughly investigated. Method: We propose a method to model the dynamic QT-RR coupling by defining a transfer function characterizing the relationship between a QT interval and its previous RR intervals measured from ambulatory Holter recordings. Three parameters are used to characterize the QT-RR coupling: a fast gain (Gain(F) ), a slow gain (Gain(L) ), and a time constant (τ). We investigated the values of these parameters across genders, and in genotyped LQT-1 patients with normal QTc interval duration (QTc < 470 ms). Results: The QT-RR dynamic profiles are significantly different between LQT-1 patients (97) and controls (154): LQT-1 have longer QTc interval (453 ± 35 vs. 384 ± 26 ms, P < 0.0001), and an increased dependency of the QT interval to previous RR changes revealed by a larger Gain(L) (0.22 ± 0.06 vs. 0.18 ± 0.07, P < 0.0001) and Gain(F) (0.05 ± 0.02 vs. 0.03 ± 0.01, P < 0.0001). Importantly, LQT-1 patients have a faster QT dynamic response to previous RR changes described by τ: 122 ± 44 vs. 172 ± 92 beats (P < 0.0001). This faster QT dynamic response of the QT-RR dynamic coupling remained in LQT-1 patients with QTc in a normal range (<430 ms). Conclusions: The measurement of QT-RR dynamic coupling could be used in patients suspected to carry a concealed form of the LQT-1 syndrome, or to provide insights into the types of arrhythmogenic triggers a patient may be prone to. |
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Authors:
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Josef Halamek; Jean-Philippe Couderc; Pavel Jurak; Vlastimil Vondra; Wojciech Zareba; Ivo Viscor; Pavel Leinveber M Sc |
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Publication Detail:
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Type: Journal Article Date: 2012-08-13 |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 17 ISSN: 1542-474X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 323-30 Citation Subset: IM |
Copyright Information:
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© 2012, Wiley Periodicals, Inc. |
Affiliation:
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Institute of Scientific Instruments, AS CR, Brno, Czech Republic Center for Quantitative Electrocardiography and Cardiac Safety, Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, NY, USA International Clinical Research Center, Center of Biomedical Engineering, St. Anne's University Hospital, Brno, Czech Republic. |
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