Document Detail


Measles virus infection causes transient depletion of activated T cells from peripheral circulation.
MedLine Citation:
PMID:  10382817     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Natural measles virus infection as well as vaccination with attenuated measles virus induce temporary immunosuppression, which is responsible for part of the morbidity and mortality associated with measles. The underlying molecular mechanisms are not known. Recently, in vitro studies have revealed a marked increase of LFA-1 expression of lymphocytes in the presence of infectious measles virus.
OBJECTIVES: In order to further investigate immune dysfunction in measles we analyzed the expression of leukocyte function-associated antigen 1 (LFA-1) on ex vivo derived circulating human T cells.
STUDY DESIGN: Expression of LFA-1 was measured by flow cytometry using monoclonal antibodies directed against CD11a and CD18. LFA-1 expression was followed in the course of infection in four adult seronegative vaccinees and in four patients with natural measles.
RESULTS: There was a remarkable loss of LFA-1-bright cells during natural measles and after measles vaccination. The number of LFA-1-bright cells reached a minimum on day 7-14 after vaccination, and at the onset of rash during natural measles infection, and approached normal levels within 3-5 weeks.
CONCLUSION: It is suggested that measles virus infection interferes with lymphocyte trafficking and reallocation. Disruption of recirculation and random homing of lymphocytes might contribute to the immunosuppression, which is characteristic for measles virus infection.
Authors:
R Nanan; B Chittka; M Hadam; H W Kreth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology     Volume:  12     ISSN:  1386-6532     ISO Abbreviation:  J. Clin. Virol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-26     Completed Date:  1999-08-26     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9815671     Medline TA:  J Clin Virol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  201-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Humans
Leukocytes, Mononuclear / immunology
Lymphocyte Activation
Lymphocyte Depletion
Lymphocyte Function-Associated Antigen-1 / biosynthesis*
Measles / immunology*
Measles Vaccine / immunology
Measles virus
Mumps / immunology
Mumps Vaccine / immunology
T-Lymphocyte Subsets / immunology
T-Lymphocytes / immunology*
Vaccination
Chemical
Reg. No./Substance:
0/Lymphocyte Function-Associated Antigen-1; 0/Measles Vaccine; 0/Mumps Vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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