Document Detail

Measles virus L protein evidences elements of ancestral RNA polymerase.
MedLine Citation:
PMID:  2835864     Owner:  NLM     Status:  MEDLINE    
We have determined the nucleotide sequence of the measles virus (MV) L gene using a cDNA library encompassing the entire MV genome (J. Crowley et al. (1987) Intervirology, 28, 65-77). The L gene is 6639 nucleotides in length, and contains a single long open reading frame that could code for a protein of 247,611 kDa. Both the L gene and in particular the predicted L protein of MV bear substantial homology to their counterparts in Sendai virus and Newcastle disease virus, suggesting that the multifunctional nature of paramyxovirus L proteins imposes strong evolutionary constraints. The predicted MV L protein also contains distinct elements of a postulated ancestral RNA polymerase.
B M Blumberg; J C Crowley; J I Silverman; J Menonna; S D Cook; P C Dowling
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Virology     Volume:  164     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-21     Completed Date:  1988-06-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  487-97     Citation Subset:  IM    
Neurology Service, East Orange VA Medical Center, New Jersey 07019.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA-Directed RNA Polymerases / genetics*
Endonucleases / pharmacology
Genes, Viral*
Measles virus / genetics*
Molecular Sequence Data
RNA Replicase*
Sequence Homology, Nucleic Acid
Single-Strand Specific DNA and RNA Endonucleases
Viral Proteins / genetics*
Reg. No./Substance:
0/Viral Proteins; EC protein, vesicular stomatitis virus; EC Replicase; EC RNA Polymerases; EC 3.1.-/Endonucleases; EC Specific DNA and RNA Endonucleases

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