Document Detail

Means for load variation during echocardiographic assessment of the Frank-Starling relationship.
MedLine Citation:
PMID:  10511647     Owner:  NLM     Status:  MEDLINE    
Because minimally invasive methods of preload variation are not validated for load-insensitive indexes of cardiac performance, intravenous nitroglycerin (NTG), phenylephrine, and saline solution (VOL) boluses were used in blocked and intact autonomic states to alter load and were compared with vena caval occlusion in the assessment of preload recruitable stroke work relationships between stroke work and left ventricular end-diastolic volume in dogs. In both autonomic states NTG and VOL produced comparable linear relationships. NTG and saline solution were combined with noninvasive measurements of left ventricular pressure and volume to construct echocardiographic relationships between stroke work and left ventricular end-diastolic cross-sectional area; NTG produced linear relationships similar to vena caval occlusion. Therefore NTG and VOL reliably alter load in constructing preload recruitable stroke work relationships, and NTG may be used with noninvasive measurements to provide load-insensitive estimates of cardiac function in a minimally invasive manner.
B Z Atkins; S C Silvestry; J W Davis; J A Kisslo; D D Glower
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  12     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-30     Completed Date:  1999-11-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  792-800     Citation Subset:  IM; S    
Departments of Surgery, Medicine, and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Analysis of Variance
Cardiotonic Agents / administration & dosage
Hemodynamics / drug effects,  physiology
Image Processing, Computer-Assisted
Linear Models
Nitroglycerin / administration & dosage
Papillary Muscles / drug effects,  physiology
Phenylephrine / administration & dosage
Sodium Chloride / administration & dosage
Vasodilator Agents / administration & dosage
Ventricular Function, Left / drug effects,  physiology*
Grant Support
Reg. No./Substance:
0/Cardiotonic Agents; 0/Vasodilator Agents; 55-63-0/Nitroglycerin; 59-42-7/Phenylephrine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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