| Meaning of low-density lipoprotein-apheresis for hypercholesterolemic patients at high risk for recurrence of coronary heart disease. | |
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MedLine Citation:
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PMID: 12423532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The goal of cholesterol-lowering therapy in hypercholesterolemic patients at high risk for recurrence of coronary heart disease (CHD) is the prevention of acute coronary syndrome by stabilization of coronary atheromatous plaque. We often encounter patients in whom it is difficult to maintain the serum cholesterol level at a desirable level with dietary therapy and drug treatment, despite the development and use of statins. For secondary prevention in patients who are at high risk for the recurrence of CHD and whose cholesterol level cannot be controlled by drugs alone, low-density lipoprotein (LDL)-apheresis therapy, which involves removal of LDL through extracorporeal circulation, is now available. Many reports concerning improvement of vascular endothelial function, improvement of myocardial ischemia, regression of coronary atherosclerotic lesions, stabilization of coronary plaque, and reduction in the incidence of cardiac events as a result of LDL-apheresis treatment have been published in various countries. We believe that LDL-apheresis should be performed on hypercholesterolemic patients with existing CHD for whom diet and maximum cholesterol-lowering drug therapies have been ineffective or not tolerated and whose LDL cholesterol level is 160 mg/dL or higher. |
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Authors:
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Nobuhiko Koga |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis Volume: 6 ISSN: 1091-6660 ISO Abbreviation: Ther Apher Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-11-08 Completed Date: 2003-01-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9706703 Medline TA: Ther Apher Country: United States |
Other Details:
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Languages: eng Pagination: 372-80 Citation Subset: IM |
Affiliation:
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Shin-Koga Hospital, Kurume, Japan. akikokhp@kureme.ktarn.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Component Removal* Cholesterol, LDL / blood* Coronary Artery Disease / blood, therapy Coronary Disease / blood, etiology, physiopathology, prevention & control* Endothelium, Vascular / physiopathology Humans Hypercholesterolemia / complications, physiopathology, therapy* Myocardial Ischemia / therapy Recurrence / prevention & control Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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