Document Detail

Mean platelet volume is increased in chronic hepatitis C patients with advanced fibrosis.
MedLine Citation:
PMID:  22572524     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Liver biopsy is the gold standard procedure for documenting liver damage in chronic hepatitis C (CHC), as for many other chronic liver diseases. Mean platelet volume (MPV) is a laboratory marker obtained from complete blood count (CBC) analysers in routine clinical practice. The goal of the present study was to evaluate whether MPV would be useful in predicting liver histologic severity in CHC.
PATIENTS AND METHODS: A total of 59 patients with CHC and 25 control subjects were recruited into the present study. There were 26 men and 33 women in the CHC group and 12 men and 13 women in the control group. MPV was recorded at the time of admission. The clinical characteristics of CHC patients, including demographics, laboratory and liver biopsy findings, were reviewed.
RESULTS: A statistically significant increase in MPV values was observed in CHC patients (8.54 ± 0.63 fL) compared to healthy controls (7.65 ± 0.42 fL) (P < 0.001). Moreover, MPV values were significantly higher among patients with advanced fibrosis as compared to those with mild fibrosis (8.99 ± 0.57 fL vs. 8.19 ± 0.50 fL P < 0.001). Receiver operator characteristic (ROC) curve analysis suggested that the optimum cut-off point for MPV value in advanced fibrosis was 8.75 fL. (Sensitivity: 80.8%, specificity: 81.8%, positive predictive value [PPV] 77.8%, negative predictive value [NPV] 84.4%, accuracy 81.3%, AUC: 0.98 P < 0.001)
CONCLUSION: The current study showed that MPV is increased in CHC with advanced fibrosis. Calculation of MPV along with the use of other markers may give further information about liver fibrosis severity in CHC.
Tugrul Purnak; Sehmus Olmez; Serkan Torun; Cumali Efe; Abdurrahim Sayilir; Ersan Ozaslan; Ilyas Tenlik; Ismail Hakki Kalkan; Yavuz Beyazit; Osman Yuksel
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Publication Detail:
Type:  Journal Article     Date:  2012-05-07
Journal Detail:
Title:  Clinics and research in hepatology and gastroenterology     Volume:  37     ISSN:  2210-741X     ISO Abbreviation:  Clin Res Hepatol Gastroenterol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-18     Revised Date:  2014-01-15    
Medline Journal Info:
Nlm Unique ID:  101553659     Medline TA:  Clin Res Hepatol Gastroenterol     Country:  France    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
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MeSH Terms
Disease Progression
Hepatitis C, Chronic / blood*,  complications*
Liver Cirrhosis / blood*,  complications*
Middle Aged
Platelet Count
Retrospective Studies
Severity of Illness Index
Comment In:
Clin Res Hepatol Gastroenterol. 2013 Dec;37(6):e121-3   [PMID:  24176814 ]

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