Document Detail

Mean platelet volume is elevated in patients with myocardial infarction with normal coronary arteries, as in patients with myocardial infarction with obstructive coronary artery disease.
MedLine Citation:
PMID:  19347745     Owner:  NLM     Status:  MEDLINE    
Although the majority of cases of acute myocardial infarction are caused by atherosclerotic coronary artery disease (CAD), it can also occur in people with normal coronary arteries. One of the possible mechanisms causing myocardial infarction with normal coronary arteries (MINC) is transient occlusion of the infarct-related artery owing to platelet hyperactivity and thrombosis. Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with unstable angina and myocardial infarction in the setting of obstructive CAD. However, the value of MPV in patients with MINC is not known. The aim of this study was to assess the MPV in patients with MINC. We retrospectively studied 47 patients with MINC, 63 patients with myocardial infarction resulting from single coronary artery disease (MISC) and 55 control subjects. MPV values were recorded in all study patients and control subjects. The MPV values of patients with MINC and MISC were significantly higher than those of the control group (9.1+/-1.8 and 9.4+/-1.0 versus 8.3+/-1.4 fl; p<0.05 and p<0.001, respectively). There were no significant differences in MPV values between the MINC and MISC groups. We show for the first time that MPV is significantly higher in patients with MINC compared with control subjects. Concurring with previous studies, we also show that MPV is significantly higher in patients with MISC compared to control subjects.
Ercan Varol; Atilla Icli; Mehmet Ozaydin; Dogan Erdogan; Akif Arslan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  69     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-03     Completed Date:  2009-11-04     Revised Date:  2010-02-17    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  570-4     Citation Subset:  IM    
Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
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MeSH Terms
Blood Platelets / physiology*
Case-Control Studies
Coronary Artery Disease / complications*,  physiopathology*
Coronary Occlusion / complications*,  physiopathology*
Coronary Vessels / physiopathology*
Middle Aged
Myocardial Infarction / physiopathology*
Platelet Activation
Young Adult
Comment In:
Scand J Clin Lab Invest. 2010 Feb;70(1):6; author reply 7   [PMID:  19958067 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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