Document Detail

Mean diffusivity and fractional anisotropy as indicators of disease and genetic liability to schizophrenia.
MedLine Citation:
PMID:  21306734     Owner:  NLM     Status:  MEDLINE    
The goals of this study were to first determine whether the fractional anisotropy (FA) and mean diffusivity (MD) of major white matter pathways associate with schizophrenia, and secondly to characterize the extent to which differences in these metrics might reflect a genetic predisposition to schizophrenia. Differences in FA and MD were identified using a comprehensive atlas-based tract mapping approach using diffusion tensor imaging and high-resolution structural data from 35 patients, 28 unaffected first-degree relatives of patients, 29 community controls, and 14 first-degree relatives of controls. Schizophrenia patients had significantly higher MD in the following tracts compared to controls: the right anterior thalamic radiations, the forceps minor, the bilateral inferior fronto-occipital fasciculus (IFO), the temporal component of the left superior longitudinal fasciculus (tSLF), and the bilateral uncinate. FA showed schizophrenia effects and a linear relationship to genetic liability (represented by schizophrenia patients, first-degree relatives, and controls) for the bilateral IFO, the left inferior longitudinal fasciculus (ILF), and the left tSLF. Diffusion tensor imaging studies have previously identified white matter abnormalities in all three of these tracts in schizophrenia; however, this study is the first to identify a significant genetic liability. Thus, FA of these three tracts may serve as biomarkers for studies seeking to identify how genes influence brain structure predisposing to schizophrenia. However, differences in FA and MD in frontal and temporal white matter pathways may be additionally driven by state variables that involve processes associated with the disease.
Kristi A Clark; Keith H Nuechterlein; Robert F Asarnow; Liberty S Hamilton; Owen R Phillips; Nathan S Hageman; Roger P Woods; Jeffry R Alger; Arthur W Toga; Katherine L Narr
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-08
Journal Detail:
Title:  Journal of psychiatric research     Volume:  45     ISSN:  1879-1379     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-14     Completed Date:  2011-08-30     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  980-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Antipsychotic Agents / therapeutic use
Brain / pathology*
Brief Psychiatric Rating Scale
Diffusion Magnetic Resonance Imaging*
Dominance, Cerebral / physiology
Genetic Predisposition to Disease / genetics*
Image Processing, Computer-Assisted*
Middle Aged
Neural Pathways / pathology*
Reference Values
Schizophrenia / diagnosis*,  drug therapy,  genetics*
Schizophrenic Psychology*
Young Adult
Grant Support
K01 MH073990/MH/NIMH NIH HHS; K01 MH073990-01A1/MH/NIMH NIH HHS; MH037705/MH/NIMH NIH HHS; MH049716/MH/NIMH NIH HHS; MH066286/MH/NIMH NIH HHS; MH073990/MH/NIMH NIH HHS; P41 RR013642/RR/NCRR NIH HHS; P41 RR013642/RR/NCRR NIH HHS; P41 RR013642-02/RR/NCRR NIH HHS; P50 MH066286/MH/NIMH NIH HHS; P50 MH066286-01A1/MH/NIMH NIH HHS; R01 MH037705/MH/NIMH NIH HHS; R01 MH037705-09S1/MH/NIMH NIH HHS; R01 MH049716/MH/NIMH NIH HHS; R01 MH049716-05/MH/NIMH NIH HHS; U54 RR021813/RR/NCRR NIH HHS; U54 RR021813/RR/NCRR NIH HHS; U54 RR021813-01/RR/NCRR NIH HHS
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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