Document Detail


Mean blood pressure, pulse pressure and grade of hypertension in untreated hypertensive patients with sleep-related breathing disorder.
MedLine Citation:
PMID:  11330870     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test the hypothesis that sleep-related breathing disorder (SRBD) is associated with increasing severity of cardiovascular risk markers. DESIGN: A cross-sectional study of sleep laboratory patients. SETTING: University Hospital Sleep Disorders Centre. PATIENTS: We studied 591 patients referred for a sleep study, all of them without a history of systemic hypertension. INTERVENTIONS: Clinical interview, two unattended sleep studies, and assessment of office blood pressure, cholesterol concentration, alcohol and nicotine consumption and daytime blood gases. MAIN OUTCOME MEASURE: Post-hoc analysis of different cardiovascular risk markers: mean blood pressure, pulse pressure, and the type and grade of systemic hypertension. RESULTS: Patients were classified as normotensive (blood pressure < 140/90 mmHg, n = 228) or hypertensive (blood pressure > or = 140/90 mmHg, n = 363) according to office blood pressure measurements. Mixed (systolic and diastolic) hypertension was the most common type of hypertension (n = 182), followed by isolated diastolic hypertension (n = 101), borderline isolated systolic hypertension (n = 70), and isolated systolic hypertension (n = 10). The frequency of mixed hypertension increased with SRBD activity (P < 0.05) and respiratory disturbance index (RDI; the number of breathing disorders per hour of estimated sleep time) was increased in those with mixed hypertension compared with those with normotension (24.8 compared with 15.7; t test: P < 0.01). In hypertensive patients classified as having grades 1 -3 of hypertension (n = 265, 80 and 18, respectively), there was a progressive increase in RDI (18.9, 27.2 and 30.3, respectively, P < 0.01). Mean blood pressure increased significantly with RDI. Pulse pressure increased significantly with age (P < 0.001), but was unrelated to the degree of SRBD. CONCLUSION: We conclude that mean blood pressure and the severity of hypertension, but not pulse pressure, increase with the severity of the SRBD.
Authors:
L Grote; J Hedner; J H Peter
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  19     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-01     Completed Date:  2001-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  683-90     Citation Subset:  IM    
Affiliation:
Sleep Disorders Centre, Department of Pulmonary Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden. ludger.grote@pharm.gu.se
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure*
Cardiovascular Diseases / etiology
Cross-Sectional Studies
Female
Humans
Hypertension / complications*,  physiopathology*
Male
Middle Aged
Pressure
Pulse*
Risk Factors
Severity of Illness Index
Sleep Apnea Syndromes / complications*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Choice of drug treatment for obesity-related hypertension: where is the evidence?
Next Document:  Is coronary risk an accurate surrogate for cardiovascular risk for treatment decisions in mild hyper...