| Mean arterial pressure nonlinearity in an elastic circulatory system subjected to different hematocrits. | |
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MedLine Citation:
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PMID: 20878440 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The level of hematocrit (Hct) is known to affect mean arterial pressure (MAP) by influencing blood viscosity. In the healthy population, an increase in Hct (and corresponding increase in viscosity) tends to raise MAP. However, data from a clinical study of type 2 diabetic patients indicate that this relationship is not universal. Instead, individuals in the lower levels of Hct range display a decrease in MAP for a given rise in Hct. After reaching a minimum, this trend is reversed, so that further increases in Hct lead to increases in MAP. We hypothesize that this anomalous behavior occurs due to changes in the circulatory autoregulation mechanism. To substantiate this hypothesis, we develop a physically based mathematical model that incorporates autoregulation mechanisms. Our model replicates the anomalous U-shaped relationship between MAP and Hct found in diabetic patients in the same range of Hct variability. |
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Authors:
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Tom Branigan; Diogo Bolster; Beatriz Y Salazar Vázquez; Marcos Intaglietta; Daniel M Tartakovsky |
Publication Detail:
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Type: Journal Article Date: 2010-09-29 |
Journal Detail:
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Title: Biomechanics and modeling in mechanobiology Volume: 10 ISSN: 1617-7940 ISO Abbreviation: Biomech Model Mechanobiol Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135325 Medline TA: Biomech Model Mechanobiol Country: Germany |
Other Details:
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Languages: eng Pagination: 591-8 Citation Subset: IM; S |
Affiliation:
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School of Medicine, Royal College of Surgeons, Dublin, Ireland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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