Document Detail


Meal pattern of male rats maintained on histidine-, leucine-, or tyrosine-supplemented diet.
MedLine Citation:
PMID:  17372311     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Food intake is known to be affected by macronutrient composition of the diet, and protein manipulation has been reported to alter food intake, but the effect of individual amino acids on eating behavior has not been fully studied. This study investigated the effect of diet supplementation with three individual amino acids on meal pattern in male rats. RESEARCH METHODS AND PROCEDURES: Thirty-two Sprague-Dawley rats were randomly divided into four equal groups and fed control diet or histidine (5%)-, leucine (5%)-, or tyrosine (5%)-supplemented diet for 2 weeks and were monitored for their meal pattern. RESULTS: Total food intake and feeding rate of the different groups were not affected, although other components of meal pattern were altered. Histidine supplementation reduced diurnal meal size by 42% (p < 0.05), whereas that of leucine increased nocturnal meal size by approximately 35% (p < 0.05). Tyrosine supplementation increased food intake of the nocturnal period and decreased that of the diurnal period. Both histidine and tyrosine supplementation elevated fasting plasma insulin levels and suppressed fasting glucose significantly. DISCUSSION: Individual amino acids were found to alter meal pattern differently. Further investigations are required to dissect the involvement of central and peripheral factors in these alterations.
Authors:
Maya S Bassil; Nahla Hwalla; Omar A Obeid
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  15     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-20     Completed Date:  2007-05-15     Revised Date:  2008-01-21    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  616-23     Citation Subset:  IM    
Affiliation:
Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, P.O. Box 11-0236, Beirut, Lebanon.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / analysis
Body Weight
Diet
Dietary Supplements*
Eating / drug effects
Feeding Behavior / physiology*
Histidine / administration & dosage*,  blood
Insulin / blood
Leucine / administration & dosage*,  blood
Male
Rats
Rats, Sprague-Dawley
Tyrosine / administration & dosage*,  blood
Chemical
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 55520-40-6/Tyrosine; 61-90-5/Leucine; 71-00-1/Histidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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