| Meal induced rectosigmoid tone modification: a low caloric meal accurately separates functional and organic gastrointestinal disease patients. | |
| | |
MedLine Citation:
|
PMID: 16434428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIMS: Diagnosis of irritable bowel syndrome (IBS) is based on arbitrary criteria due to the lack of an accurate diagnostic test. The aim of this study was to evaluate whether rectosigmoid tone modification after a meal represents an accurate diagnostic approach. METHODS: In a secondary care setting, 32 constipation predominant and 24 diarrhoea predominant IBS patients, 10 functional diarrhoea and 10 functional constipation patients, 29 organic gastrointestinal disease patients, and 10 healthy volunteers underwent a rectal barostat test to measure fasting and postprandial rectosigmoid tone. Rectosigmoid response was assessed following three meals containing different amounts of calories: 200 kcal, 400 kcal and 1000 kcal. RESULTS: After 200 kcal, healthy volunteers and patients with organic diseases showed a reduction in rectosigmoid volume of at least 28% of fasting volume, indicating a meal induced increase in muscle tone. In contrast, patients with diarrhoea predominant IBS showed dilation of the rectosigmoid colon, indicative of reduced tone, and patients with constipation predominant IBS showed a mild volume reduction or no modification. Functional diarrhoea and constipation patients showed rectosigmoid tone modification resembling that of the corresponding IBS subtype. A 400 kcal meal normalised rectosigmoid tone in more than half of the constipation predominant IBS patients but none of the diarrhoea predominant IBS patients. In contrast, a 1000 kcal meal normalised tone response in all IBS patients. Sensitivity of the test was 100%, specificity 93%, positive predictive value 96%, and negative predictive value 100%. CONCLUSION: A postprandial reduction in rectosigmoid tone of at least 28% of fasting value after a low caloric meal accurately separates organic and functional gastrointestinal disease patients. This parameter may therefore be used in the positive diagnosis of IBS. |
| | |
Authors:
|
M Di Stefano; E Miceli; A Missanelli; S Mazzocchi; G R Corazza |
Related Documents
:
|
19543748 - Genetic diversity of dientamoeba fragilis isolates of irritable bowel syndrome patients... 10334488 - The neuropathology of intestinal failure and small bowel transplantation. 10532258 - Intestinal adaptation in pediatric patients with short-bowel syndrome. 18560408 - Keratinocyte growth factor is effective in the prevention of intestinal mucositis in pa... 22950068 - Clinical usefulness of cell-based indirect immunofluorescence assay for the detection o... 22235378 - The natural history and clinical presentation of cervical spondylotic myelopathy. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article Date: 2006-01-24 |
Journal Detail:
|
Title: Gut Volume: 55 ISSN: 1468-3288 ISO Abbreviation: Gut Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-09-12 Completed Date: 2008-01-14 Revised Date: 2013-06-07 |
Medline Journal Info:
|
Nlm Unique ID: 2985108R Medline TA: Gut Country: England |
Other Details:
|
Languages: eng Pagination: 1409-14 Citation Subset: AIM; IM |
Affiliation:
|
I Department of Medicine, IRCCS S. Matteo Hospital, University of Pavia, P le Golgi 5, 27100, Pavia, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Caloric Restriction Case-Control Studies Colon, Sigmoid / physiology* Constipation / etiology*, physiopathology Diarrhea / etiology*, physiopathology Fasting / physiology Female Food* Humans Irritable Bowel Syndrome / diagnosis*, physiopathology Male Middle Aged Postprandial Period Prospective Studies Rectum / physiology* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endothelin-1 contributes to maintenance of systemic but not portal haemodynamics in patients with ea...
Next Document: Health consequences of the first Persian Gulf War on French troops.