Document Detail


Meal frequency patterns determine the phase of mouse peripheral circadian clocks.
MedLine Citation:
PMID:  23050095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral circadian clocks in mammals are strongly entrained by light-dark and eating cycles. Their physiological functions are maintained by the synchronization of the phase of organs via clock gene expression patterns. However, little is known about the adaptation of peripheral clocks to the timing of multiple daily meals. Here, we investigated the effect of irregular eating patterns, in terms of timing and volume, on their peripheral clocks in vivo. We found that the phase of the peripheral clocks was altered by the amount of food and the interval between feeding time points but was unaffected by the frequency of feeding, as long as the interval remained fixed. Moreover, our results suggest that a late dinner should be separated into 2 half-dinners in order to alleviate the effect of irregular phases of peripheral clocks.
Authors:
Hiroaki Kuroda; Yu Tahara; Keisuke Saito; Nobuaki Ohnishi; Yuji Kubo; Yasuhiro Seo; Makiko Otsuka; Yuta Fuse; Yuki Ohura; Akiko Hirao; Shigenobu Shibata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-05
Journal Detail:
Title:  Scientific reports     Volume:  2     ISSN:  2045-2322     ISO Abbreviation:  Sci Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-03-05     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101563288     Medline TA:  Sci Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  711     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animal Nutritional Physiological Phenomena*
Animals
Circadian Clocks / physiology*
Circadian Rhythm / physiology*
Eating / physiology
Feeding Behavior / physiology*
Gene Expression
Gene Knock-In Techniques
Genes, Reporter
Kidney / metabolism
Light
Liver / metabolism
Luciferases
Mice
Mice, Transgenic
Period Circadian Proteins / genetics,  metabolism
Photoperiod
Submandibular Gland / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Per2 protein, mouse; 0/Period Circadian Proteins; EC 1.13.12.-/Luciferases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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