| Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects. | |
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MedLine Citation:
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PMID: 16523409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is mounting evidence that elevated circulating concentrations of glycated insulin play a role in insulin resistance in type 2 diabetes. This study evaluated the secretion of glycated insulin in response to enteral stimulation in type 2 diabetic subjects. Following a mixed meal (450 kcal; 44 % carbohydrate; 40 % fat; 16 % protein), glycated insulin rose 10-fold to peak (60 min) at 104.5 +/- 25.0 pmol/l (p < 0.001), representing 22 % total circulating insulin. The response paralleled early rises in insulin and C-peptide, which peaked at 90 min and were more protracted. Maximum glucose concentrations were observed at 50 min. These data indicate that type 2 diabetic subjects exhibit a rapid meal-induced release of glycated insulin from readily releasable pancreatic beta-cell stores, which might contribute to impaired glucose homeostasis following enteral nutrition. |
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Authors:
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A M McKillop; J R Lindsay; S Au; K I Mahood; F P M O'Harte; P R Flatt; P M Bell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 38 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-03-08 Completed Date: 2006-05-18 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 94-7 Citation Subset: IM |
Affiliation:
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School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland. am.mckillop@ulster.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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analysis C-Peptide / blood* Diabetes Mellitus, Type 2 / blood* Female Food* Homeostasis Humans Insulin / blood* Insulin-Secreting Cells / metabolism Male Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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