Document Detail

Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects.
MedLine Citation:
PMID:  16523409     Owner:  NLM     Status:  MEDLINE    
There is mounting evidence that elevated circulating concentrations of glycated insulin play a role in insulin resistance in type 2 diabetes. This study evaluated the secretion of glycated insulin in response to enteral stimulation in type 2 diabetic subjects. Following a mixed meal (450 kcal; 44 % carbohydrate; 40 % fat; 16 % protein), glycated insulin rose 10-fold to peak (60 min) at 104.5 +/- 25.0 pmol/l (p < 0.001), representing 22 % total circulating insulin. The response paralleled early rises in insulin and C-peptide, which peaked at 90 min and were more protracted. Maximum glucose concentrations were observed at 50 min. These data indicate that type 2 diabetic subjects exhibit a rapid meal-induced release of glycated insulin from readily releasable pancreatic beta-cell stores, which might contribute to impaired glucose homeostasis following enteral nutrition.
A M McKillop; J R Lindsay; S Au; K I Mahood; F P M O'Harte; P R Flatt; P M Bell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  38     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-05-18     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland.
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MeSH Terms
Blood Glucose / analysis
C-Peptide / blood*
Diabetes Mellitus, Type 2 / blood*
Insulin / blood*
Insulin-Secreting Cells / metabolism
Time Factors
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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