| Mcl-1; the molecular regulation of protein function. | |
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MedLine Citation:
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PMID: 20540941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apoptosis, an essential and basic biological phenomenon, is regulated in a complex manner by a multitude of factors. Myeloid cell leukemia 1 (Mcl-1), an anti-apoptotic member of the B-cell lymphoma 2 (Bcl-2) family of apoptosis-regulating proteins, exemplifies a number of the mechanisms by which a protein's contribution to cell fate may be modified. The N-terminus of Mcl-1 is unique amongst the Bcl-2 family, in that it is rich in experimentally confirmed and putative regulatory residues and motifs. These include sites for ubiquitination, cleavage and phosphorylation, which influence the protein's stability, localisation, dimerization and function. Here we review what is known about the regulation of Mcl-1 expression and function, with particular focus on post-translational modifications and how phosphorylation interconnects the complex molecular control of Mcl-1 with cellular state. |
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Authors:
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Luke W Thomas; Connie Lam; Steven W Edwards |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-11 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-07-27 Revised Date: 2011-12-01 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2981-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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School of Biological Sciences, University of Liverpool, Liverpool, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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genetics B-Lymphocytes / metabolism Dimerization Humans Leukemia / genetics, metabolism* Leukemia, Myeloid / genetics Lymphoma, B-Cell / genetics Myeloid Cells / metabolism Myeloid Progenitor Cells / metabolism Phosphorylation Protein Processing, Post-Translational Protein Structure, Tertiary / genetics Proteins / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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//Arthritis Research UK |
| Chemical | |
Reg. No./Substance:
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0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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