Document Detail

Mcl-1: a highly regulated cell death and survival controller.
MedLine Citation:
PMID:  16456709     Owner:  NLM     Status:  MEDLINE    
Mcl-1 is one member of the Bcl-2 family that has a very short protein half-life. Since its identification in 1993, a great number of studies have implicated that Mcl-1 plays an important role in various cell survival pathways. However, not until recently did the molecular mechanism by which Mcl-1 antagonizes apoptosis have begun to be elucidated. Mcl-1 is rapidly degraded in response to cell death signals and is immediately re-induced by survival stimuli. These results indicate that Mcl-1 plays an apical role in many cell death and survival regulatory programs.
Hsin-Fang Yang-Yen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of biomedical science     Volume:  13     ISSN:  1021-7770     ISO Abbreviation:  J. Biomed. Sci.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-28     Completed Date:  2006-07-31     Revised Date:  2008-07-09    
Medline Journal Info:
Nlm Unique ID:  9421567     Medline TA:  J Biomed Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  201-4     Citation Subset:  IM    
Institute of Molecular Biology, Academia Sinica, 128 Yen-Jiou Yuan Road, Section 2, Nankang, Taipei, 11529, Taiwan.
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MeSH Terms
Apoptosis Regulatory Proteins
Cell Death
Cell Survival
Neoplasm Proteins / metabolism,  physiology*
Proto-Oncogene Proteins c-bcl-2 / metabolism,  physiology*
Signal Transduction
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Neoplasm Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/myeloid cell leukemia sequence 1 protein

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