| Mcl-1: a highly regulated cell death and survival controller. | |
| | |
MedLine Citation:
|
PMID: 16456709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mcl-1 is one member of the Bcl-2 family that has a very short protein half-life. Since its identification in 1993, a great number of studies have implicated that Mcl-1 plays an important role in various cell survival pathways. However, not until recently did the molecular mechanism by which Mcl-1 antagonizes apoptosis have begun to be elucidated. Mcl-1 is rapidly degraded in response to cell death signals and is immediately re-induced by survival stimuli. These results indicate that Mcl-1 plays an apical role in many cell death and survival regulatory programs. |
| | |
Authors:
|
Hsin-Fang Yang-Yen |
Related Documents
:
|
11039909 - Regulation of proliferation-survival decisions is controlled by fgf1 secretion in retin... 16818639 - Overexpression of cox-2 in human osteosarcoma cells decreases proliferation and increas... 15978939 - Induction of apoptosis in k562 human leukemia cells by 2',4'-dihydroxy-6'-methoxy-3',5'... 20652449 - Knockdown of eif4e suppresses cell growth and migration, enhances chemosensitivity and ... 10809229 - Growth hormone prevents apoptosis through activation of nuclear factor-kappab in interl... 10612539 - B-cell leukemia protein-2 and peptide yy chemotherapy resistance in colon cancer. 171679 - Scanning electron microscopy of glucocrticoid-treated hepatocytes and hepatoma cells in... 17255799 - Particulate matter in the environment: pulmonary and cardiovascular effects. 18199979 - Comparative analysis of apoptosis induction by selenium compounds in human lymphoblasti... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Journal of biomedical science Volume: 13 ISSN: 1021-7770 ISO Abbreviation: J. Biomed. Sci. Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-03-28 Completed Date: 2006-07-31 Revised Date: 2008-07-09 |
Medline Journal Info:
|
Nlm Unique ID: 9421567 Medline TA: J Biomed Sci Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 201-4 Citation Subset: IM |
Affiliation:
|
Institute of Molecular Biology, Academia Sinica, 128 Yen-Jiou Yuan Road, Section 2, Nankang, Taipei, 11529, Taiwan. imbyy@gate.sinica.edu.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Apoptosis Regulatory Proteins Cell Death Cell Survival Humans Neoplasm Proteins / metabolism, physiology* Proto-Oncogene Proteins c-bcl-2 / metabolism, physiology* Signal Transduction |
| Chemical | |
Reg. No./Substance:
|
0/Apoptosis Regulatory Proteins; 0/Neoplasm Proteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/myeloid cell leukemia sequence 1 protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular cloning, expression and characterization of the zebrafish bram1 gene, a BMP receptor-assoc...
Next Document: The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death re...