| Mcl-1 is essential for germinal center formation and B cell memory. | |
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MedLine Citation:
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PMID: 20929728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphocyte survival during immune responses is controlled by the relative expression of pro- and anti-apoptotic molecules, regulating the magnitude, quality, and duration of the response. We investigated the consequences of deleting genes encoding the anti-apoptotic molecules Mcl1 and Bcl2l1 (Bcl-x(L)) from B cells using an inducible system synchronized with expression of activation-induced cytidine deaminase (Aicda) after immunization. This revealed Mcl1 and not Bcl2l1 to be indispensable for the formation and persistence of germinal centers (GCs). Limiting Mcl1 expression reduced the magnitude of the GC response with an equivalent, but not greater, effect on memory B cell formation and no effect on persistence. Our results identify Mcl1 as the main anti-apoptotic regulator of activated B cell survival and suggest distinct mechanisms controlling survival of GC and memory B cells. |
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Authors:
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Ingela Vikstrom; Sebastian Carotta; Katja Lüthje; Victor Peperzak; Philipp J Jost; Stefan Glaser; Meinrad Busslinger; Philippe Bouillet; Andreas Strasser; Stephen L Nutt; David M Tarlinton |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-07 |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 330 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-14 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1095-9 Citation Subset: IM |
Affiliation:
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Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/HM804028; HM804029; HM804030; HM804031; HM804032; HM804033; HM804034; HM804035; HM804036; HM804037; HM804038; HM804039; HM804040; HM804041; HM804042; HM804043; HM804044; HM804045; HM804046; HM804047; HM804048; HM804049; HM804050; HM804051; HM804052; HM804053; HM804054; HM804055; HM804056; HM804057; HM804058; HM804059; HM804060; HM804061; HM804062; HM804063; HM804064; HM804065; HM804066; HM804067; HM804068; HM804069; HM804070; HM804071; HM804072; HM804073; HM804074; HM804075; HM804076; HM804077; HM804078; HM804079; HM804080; HM804081; HM804082; HM804083; HM804084 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Affinity B-Lymphocytes / immunology* Cell Survival Gene Deletion Germinal Center / cytology, immunology* Immunologic Memory* Mice Mice, Inbred C57BL Molecular Sequence Data Proto-Oncogene Proteins c-bcl-2 / genetics, immunology* bcl-X Protein / genetics, immunology |
| Grant Support | |
ID/Acronym/Agency:
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CA43540/CA/NCI NIH HHS; CA80188/CA/NCI NIH HHS; R01 CA043540-22/CA/NCI NIH HHS; R01 CA080188-08/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-X Protein; 0/myeloid cell leukemia sequence 1 protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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